Multicentric variant of peripheral ossifying fibroma

Area of Science:

• Oral pathology
• Periodontology
• Surgical oncology

Background:

• Peripheral ossifying fibroma (POF) typically presents as a solitary gingival overgrowth originating from periodontal ligament cells.
• Often considered a reactive or inflammatory process rather than neoplastic, POF usually begins as a painless interdental papilla enlargement.

Observation:

• This report documents an exceptionally rare case of multiple POF in a 24-year-old male.
• The lesions were surgically excised quadrant by quadrant, revealing consistent histopathologic features across all sites.

Findings:

• Histopathological analysis confirmed the diagnosis of POF, highlighting a multicentric presentation, which is exceedingly uncommon.
• This represents only the second documented case of multicentric peripheral ossifying fibroma.

Implications:

• The management of multicentric POF necessitates a multidisciplinary approach for effective treatment and recurrence prevention.
• Long-term follow-up is crucial for patients diagnosed with this rare variant of gingival overgrowth.