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Related Concept Videos

Bone Disorders01:29

Bone Disorders

8.0K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
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What is the Skeletal System?01:02

What is the Skeletal System?

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Overview
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Bone Remodeling01:40

Bone Remodeling

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Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
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The Functions of the Skeletal System01:22

The Functions of the Skeletal System

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The most apparent functions of the skeletal system are support, protection, and movement. However, bone tissue also performs several other critical metabolic functions. For one, the bone matrix acts as a reservoir for a number of minerals important to the functioning of the body, especially calcium and phosphorus. These minerals, present in the bone tissue, can be released back into the bloodstream when required. Calcium ions, for example, are essential for muscle contractions and controlling...
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Osteoclasts in Bone Remodeling01:31

Osteoclasts in Bone Remodeling

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Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during...
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The Effect of Aging on Tissues01:19

The Effect of Aging on Tissues

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Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
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Related Experiment Videos

Osteoporosis and its complications.

Matthew A Varacallo1, Ed J Fox1

  • 1Penn State Hershey Department of Orthopaedics and Rehabilitation, College of Medicine, 30 Hope Drive, Building A, Hershey, PA 17033, USA.

The Medical Clinics of North America
|July 5, 2014
PubMed
Summary

Osteoporosis significantly burdens patients and healthcare systems, necessitating greater awareness and timely diagnosis to prevent debilitating fractures. Early detection and proper management, including pharmacologic agents, are crucial for improving outcomes.

Keywords:
BisphosphonatesFragility fracturesHip fracturesOsteoporosisVertebral compression fractures

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Area of Science:

  • Bone health and metabolic disorders
  • Geriatric medicine and public health
  • Health economics and healthcare management

Background:

  • Osteoporosis poses a significant and growing burden on global healthcare systems.
  • The condition severely impacts patients' quality of life and incurs substantial direct financial costs.
  • Fragility fractures, such as hip and vertebral fractures, are major complications of untreated or undertreated osteoporosis.

Purpose of the Study:

  • To provide a comprehensive overview of the current burden of osteoporosis and its complications.
  • To emphasize the need for increased awareness and knowledge regarding osteoporosis complications.
  • To discuss strategies for improved care, including outpatient follow-up and pharmacologic treatments.

Main Methods:

  • Literature review and synthesis of existing data on osteoporosis prevalence and impact.
  • Analysis of the economic consequences of osteoporosis on healthcare systems.
  • Discussion of diagnostic approaches and therapeutic interventions for osteoporosis and fragility fractures.

Main Results:

  • Osteoporosis leads to substantial patient morbidity and mortality, particularly from hip and vertebral fractures.
  • The financial impact on healthcare systems is considerable due to fracture-related hospitalizations and long-term care.
  • Delayed diagnosis and inadequate treatment exacerbate the burden of the disease.

Conclusions:

  • Increased knowledge and awareness of osteoporosis and its complications are essential for effective management.
  • Early diagnosis before fragility fractures occur is critical for preventing severe outcomes.
  • Implementing improved care models and utilizing pharmacologic agents can mitigate the impact of osteoporosis.