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Severe hypertriglyceridemia induced pancreatitis in pregnancy
Natasha Gupta1, Seema Ahmed1, Lemuel Shaffer1
1Department of Obstetrics and Gynecology, Mount Sinai Hospital, 1500 S California Avenue, Chicago, IL 60608, USA.
Case Reports in Obstetrics and Gynecology
|July 5, 2014
Summary
Severe hypertriglyceridemia during pregnancy can cause acute pancreatitis, a rare but serious complication. This case highlights successful treatment with postpartum therapeutic plasma exchange, preventing fatal outcomes.
Area of Science:
- Obstetrics and Gynecology
- Endocrinology
- Gastroenterology
Background:
- Gestational hypertriglyceridemia is a rare condition, distinct from common causes of acute pancreatitis like gallstones or alcohol abuse.
- Pregnancy can induce lipid metabolism changes, potentially leading to severe hypertriglyceridemia.
- Familial chylomicronemia syndromes can be exacerbated by pregnancy, increasing risks.
Purpose of the Study:
- To report a case of acute pancreatitis secondary to severe gestational hypertriglyceridemia.
- To illustrate the successful management of this rare obstetric complication.
- To highlight associated severe hypertriglyceridemia-related conditions.
Main Methods:
- Case report of a patient presenting with acute pancreatitis at full term.
- Treatment involved postpartum therapeutic plasma exchange.
- Monitoring and management of associated complications including preeclampsia and chylous ascites.
Main Results:
- Successful resolution of acute pancreatitis and hypertriglyceridemia with therapeutic plasma exchange.
- Patient experienced multiple severe complications: preeclampsia, chylous ascites, retinal detachment, pleural effusion, and chronic pericarditis.
- No prior history of lipid abnormalities in four previous successful pregnancies.
Conclusions:
- Severe gestational hypertriglyceridemia is a critical condition that can lead to acute pancreatitis and other serious complications.
- Therapeutic plasma exchange is an effective treatment option for postpartum management.
- Early recognition and management are crucial to prevent potentially fatal outcomes in pregnant patients with severe hypertriglyceridemia.
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