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Updated: Apr 27, 2026

Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses
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Ampicillin: rise fall and resurgence

Dwarikadhish Kaushik1, Mudit Mohan2, Dhammraj M Borade3

  • 1Consultant Physician, Department of Critical Care Medicine, St Joseph Hospital , Mariyam Nagar, Nandgram Ghaziabad-201003, UP, India .

Journal of Clinical and Diagnostic Research : JCDR
|July 5, 2014
PubMed

Insights

Antimicrobial resistance (AMR) is a growing global threat, leading to treatment challenges. Interestingly, Salmonella is regaining susceptibility to ampicillin, offering hope against resistant infections.

Area of Science:

  • Microbiology
  • Infectious Diseases
  • Drug Resistance

Background:

  • Antimicrobial resistance (AMR) poses significant global health challenges, diminishing the efficacy of essential medicines.
  • The rise of resistant pathogens necessitates exploring alternative treatments and drug combinations for infectious diseases.

Purpose of the Study:

  • To investigate the re-emergence of ampicillin susceptibility in Salmonella strains.
  • To understand the implications of changing antimicrobial susceptibility patterns in the context of widespread AMR.

Main Methods:

  • Observational analysis of antimicrobial susceptibility trends in Salmonella.
  • Review of treatment strategies for enteric fever in response to evolving resistance patterns.

Main Results:

  • Salmonella previously resistant to ampicillin shows increasing susceptibility.
  • Resistance to alternative antimicrobials like fluoroquinolones and cephalosporins is also being reported.
  • Potential mechanisms for ampicillin's regained activity include loss of plasmid-mediated resistance or emergence of de novo susceptible strains.

Conclusions:

  • The regaining of ampicillin activity against Salmonella offers a promising development in combating antimicrobial resistance.
  • This phenomenon highlights the dynamic nature of pathogen resistance and the potential for antimicrobial efficacy to be restored.
  • Further research into the mechanisms of resistance loss is crucial, especially given the limited pipeline for new antimicrobial development.
Keywords:
AmpicillinAntimicrobial Resistance(AMR)Enteric feverMultidrug-resistant Salmonella typhi (MDRST)

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