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Late-onset cerebellar abiotrophy in a Labrador Retriever.

A Bertalan1, E N Glass, M Kent

  • 1Internal Medicine, University of Pennsylvania, 2025 Matthew J Ryan Veterinary Hospital, 3900 Delancey St, Philadelphia, PA, 19104, USA. bertalan@vet.upenn.edu.

Australian Veterinary Journal
|July 5, 2014
PubMed
Summary

A Labrador Retriever developed progressive neurological signs, including cerebellar ataxia. Diagnosis revealed late-onset cerebellar abiotrophy, a condition previously undescribed in this breed.

Keywords:
Labrador RetrieversPurkinje neurone degenerationcerebellar abiotrophycerebellar cortical degenerationceroid lipofuscinosisdogs

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Area of Science:

  • Veterinary Neurology
  • Canine Neurodegenerative Diseases

Background:

  • Cerebellar abiotrophy is a group of inherited neurodegenerative disorders affecting the cerebellum.
  • While documented in various dog breeds, it has not been previously reported in Labrador Retrievers.

Observation:

  • A 5-year-old Labrador Retriever presented with hindlimb gait abnormalities, progressing over one year to include cerebellar ataxia, vertical nystagmus, and delayed postural reactions.
  • Initial magnetic resonance imaging (MRI) of the brain appeared normal, but repeat imaging showed cerebellar size reduction.
  • Retrospective analysis using an objective algorithm confirmed a small cerebellum on the initial MRI.

Findings:

  • Postmortem histopathology revealed diffuse Purkinje cell degeneration and secondary granule cell loss in the cerebellum.
  • Pigment inclusions were observed in brainstem neurons.

Implications:

  • This case suggests late-onset cerebellar abiotrophy can occur in Labrador Retrievers.
  • The findings expand the known breed distribution for this canine neurodegenerative condition.
  • Highlights the importance of objective measurements and repeat imaging in diagnosing subtle neurological changes.