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Related Concept Videos

Three-Dimensional Analysis of Strain01:29

Three-Dimensional Analysis of Strain

787
Three-dimensional strain analysis is crucial for understanding how materials deform under stress, particularly in elastic, homogeneous materials. This method employs principal stress axes to simplify complex stress states into more understandable forms. Subjected to stress, a small cubic element within a material either expands or contracts along these axes, transforming into a rectangular parallelepiped. This transformation effectively illustrates the material's deformation. The principal...
787

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Related Experiment Video

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Evaluation of Left Ventricular Structure and Function using 3D Echocardiography
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Three-dimensional principal strain analysis for characterizing subclinical changes in left ventricular function.

Gianni Pedrizzetti1, Shantanu Sengupta2, Giuseppe Caracciolo3

  • 1Zena and Michael A. Wiener Cardiovascular Institute, Mount Sinai School of Medicine, New York, New York; Department of Engineering and Architecture, University of Trieste, Trieste, Italy.

Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography
|July 8, 2014
PubMed
Summary
This summary is machine-generated.

Principal and secondary strain analysis simplifies left ventricular subendocardial function assessment. This method effectively detects subclinical disease in hypertension patients by analyzing directional contraction patterns.

Keywords:
Left ventricleMechanicsStrainSubclinical disease

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High-frequency High-resolution Echocardiography: First Evidence on Non-invasive Repeated Measure of Myocardial Strain, Contractility, and Mitral Regurgitation in the Ischemia-reperfused Murine Heart
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Area of Science:

  • Cardiovascular Imaging
  • Echocardiography
  • Cardiac Mechanics

Background:

  • Subendocardial strain analysis using 2D and 3D echocardiography is established.
  • The optimal strain component for detecting subclinical disease remains unclear.
  • This study investigates principal and secondary strain for simplified left ventricular subendocardial assessment.

Purpose of the Study:

  • To test if principal and secondary strain analysis simplifies left ventricular subendocardial function assessment.
  • To determine if this approach circumvents the need for multidirectional strain analysis.
  • To evaluate its utility in detecting subclinical disease.

Main Methods:

  • Strain analysis performed using 2D and 3D echocardiography in 41 subjects (15 controls, 26 hypertensive patients).
  • Principal strain direction referenced myofiber geometry from diffusion tensor MRI of a human heart.
  • Incremental value of principal strain over multidirectional strain was analyzed.

Main Results:

  • In controls, 50% of subendocardial shortening was in the cross-fiber (principal) direction; this was altered in hypertensive patients (P=.01).
  • Longitudinal and circumferential strain magnitudes were similar between groups.
  • Hypertensive patients showed reduced secondary strain magnitude (P=.01), exaggerated when normalized by principal strain (P=.004).

Conclusions:

  • Two-component principal and secondary strain analysis correlates with left ventricular myofiber geometry.
  • This approach simplifies the assessment of 3D left ventricular deformation.
  • It obviates the need to assess multiple shortening and shear strain components.