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A Comparative Approach to Characterize the Landscape of Host-Pathogen Protein-Protein Interactions
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Host-pathogen co-evolution and glycan interactions

Jacques Le Pendu1, Kristina Nyström1, Nathalie Ruvoën-Clouet2

  • 1Inserm, UMR 892; CNRS, UMR 6299; Université de Nantes, IRS UN, 8 Quai Moncousu, BP 70721, 44007 Nantes cedex 1, France.

Current Opinion in Virology
|July 8, 2014
PubMed

Noroviruses and rotavirus A bind to polymorphic glycans of the histo-blood group type (HBGAs). Norovirus strains that bind to HBGAs can collectively infect all humans but each strain only infects a subgroup of the population, suggesting a past co-evolution that led to a trade-off where the human population is partly protected whilst the virus circulation is maintained. We termed 'Herd Innate Protection' the host species partial protection provided by the HBGAs polymorphism. Given its recent emergence, high virulence and HBGAs attachment, RHDV provides a model for studying calicivirus-host co-evolution. Field observations documented evolution of the virus ability to recognize the host HBGAs diversity and reciprocal strain-dependent selection of HBGA phenotypes following outbreaks, indicating host-pathogen co-evolution involving glycan polymorphisms.

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