Related Experiment Video

Updated: Apr 27, 2026

Optical Coherence Tomography Based Biomechanical Fluid-Structure Interaction Analysis of Coronary Atherosclerosis Progression
13:07

Optical Coherence Tomography Based Biomechanical Fluid-Structure Interaction Analysis of Coronary Atherosclerosis Progression

Published on: January 15, 2022

3.6K

Quantification of manual thrombus removal in patients with acute coronary syndromes: a study exploiting serial

Fabrizio Imola1, Maria Teresa Mallus, Vito Ramazzotti

  • 1aCardiology Department, San Giovanni Hospital, Rome, Italy bCentro per la Lotta contro l'Infarto (CLI) Foundation, Rome, Italy cSansavini Foundation, Ravenna, Italy dCentre for Inherited Cardiovascular Diseases, Istituto Di Ricovero e Cura a Carattere Scientifico (IRCCS) Fondazione Policlinico San Matteo, Pavia, Italy.

Journal of Cardiovascular Medicine (Hagerstown, Md.)
|July 8, 2014
PubMed

Insights

Thrombus aspiration removed 48.9% of thrombus in acute coronary syndrome patients. Optical coherence tomography (OCT) effectively quantified thrombus removal, correlating with histological analysis of aspirated material.

Area of Science:

  • Cardiovascular Medicine
  • Interventional Cardiology
  • Medical Imaging

Background:

  • Thrombus aspiration improves myocardial reperfusion in acute myocardial infarction.
  • Current assessment methods for thrombus aspiration efficacy are limited.
  • Manual thrombus aspiration is a common procedure in acute coronary syndromes.

Purpose of the Study:

  • To quantify thrombus removal using frequency domain optical coherence tomography (OCT).
  • To correlate OCT-derived thrombus removal with the size of aspirated material.
  • To assess the composition of retrieved thrombus material.

Main Methods:

  • Twenty-five acute coronary syndrome patients undergoing manual thrombus aspiration were enrolled.
  • Frequency domain optical coherence tomography (OCT) assessed thrombotic lesions before and after aspiration.
  • Aspirated material was analyzed by histology and planimetry.

Main Results:

  • Thrombus removal percentage was 48.9% as measured by OCT.
  • OCT-derived thrombus removal measurements correlated well with planimetry of aspirated material (r=0.56, P<0.01).
  • Significant residual thrombus was observed post-aspiration.

Conclusions:

  • OCT measurements of thrombus score correlate with planimetry of aspirated material.
  • Manual thrombus aspiration leaves substantial residual thrombus.
  • Cholesterol debris and inflammatory cells are frequently retrieved during aspiration.
Abstract

More Related Videos

Combined Near-infrared Fluorescent Imaging and Micro-computed Tomography for Directly Visualizing Cerebral Thromboemboli13:10

Combined Near-infrared Fluorescent Imaging and Micro-computed Tomography for Directly Visualizing Cerebral Thromboemboli

Published on: September 25, 2016

9.4K
Simultaneous Brightfield, Fluorescence, and Optical Coherence Tomographic Imaging of Contracting Cardiac Trabeculae Ex Vivo12:54

Simultaneous Brightfield, Fluorescence, and Optical Coherence Tomographic Imaging of Contracting Cardiac Trabeculae Ex Vivo

Published on: October 2, 2021

4.0K

Related Concept Videos

Acute Coronary Syndrome III: Diagnostic Studies01:30

Acute Coronary Syndrome III: Diagnostic Studies

Diagnosing acute coronary syndrome or ACS begins with a thorough patient history. Notable symptoms include central, crushing chest pain radiating to the left arm, neck, jaw, or back, along with shortness of breath, sweating (diaphoresis), nausea, vomiting, dizziness, and palpitations.It is crucial to note any history of cardiac illnesses and assess risk factors, including age, gender, smoking, hypertension, diabetes, hyperlipidemia, and a sedentary lifestyle.During physical examination, vital...
493
Acute Coronary Syndrome I: Introduction01:30

Acute Coronary Syndrome I: Introduction

Acute Coronary Syndrome (ACS) encompasses a spectrum of heart conditions caused by sudden obstruction of coronary arteries, typically resulting from the rupture of an atherosclerotic plaque and subsequent thrombus (blood clot) formation. This obstruction can lead to partial or complete blockage of blood flow, causing varying degrees of myocardial ischemia or infarction.ACS includes the following clinical entities:Unstable Angina (UA)Non-ST-Elevation Myocardial Infarction (NSTEMI)ST-Elevation...
2.0K