Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Biostatistics: Overview01:20

Biostatistics: Overview

1.2K
Biostatistics plays a crucial role in understanding and analyzing data in healthcare and biology. Biostatisticians conduct experiments, gather evidence, and draw meaningful conclusions using statistical methods and techniques. Different variables form the foundation of biostatistical analysis, allowing researchers to understand and interpret data effectively. These variables are classified into different types, each serving a specific purpose in statistical analysis.
Discrete variables are...
1.2K
Overview of Biostatistics in Health Sciences01:19

Overview of Biostatistics in Health Sciences

4.8K
Biostatistics involves the application of statistical techniques to scientific research in health-related fields, including biology and public health. These techniques are essential for designing studies, collecting data, and analyzing it to draw meaningful conclusions. Given the complexity of biological processes, particularly in studies involving human subjects, biostatistical methods are crucial for effectively organizing and interpreting data that might otherwise obscure underlying patterns...
4.8K
Feedback Regulation of Calcium Concentration01:27

Feedback Regulation of Calcium Concentration

2.9K
Calcium is an essential signaling molecule required for various cellular functions. Calcium pumps and ion channels on cell and organellar membranes, such as those on the endoplasmic reticulum (ER), regulate calcium concentrations inside the cell. They remain closed, keeping the cytosolic calcium levels low at a resting state.
Various transmembrane receptors, such as G protein-coupled receptors (GPCRs), elicit a response to extracellular signals by increasing cytosolic calcium. Activated GPCRs...
2.9K
IP3/DAG Signaling Pathway01:11

IP3/DAG Signaling Pathway

12.4K
Membrane lipids such as phosphatidylinositol (PI) are precursors for several membrane-bound and soluble second messengers. Specific kinases phosphorylate PI and produce phosphorylated inositol phospholipids. One such inositol phospholipids are the  phosphatidylinositol-4,5 bisphosphate [PI(4,5)P2], present in the inner half of the lipid bilayer. Upon ligand binding, GPCR stimulates Gq proteins to turn on phospholipase Cꞵ. Activated phospholipase Cꞵ cleaves PI(4,5)P2 and...
12.4K
Flow Cytometry01:23

Flow Cytometry

13.2K
The development of flow cytometry techniques began in 1934 with initial attempts by Andrew Moldavan, a bacteriologist who counted the cells in a flowing capillary system. Moldavan pumped cells through a capillary tube focused under a microscope for visualization. The invention of photometry allowed the measurement of differentially-stained cells, and Louis Kamentsky developed the first multiparameter flow cytometer in 1965 to identify and count the cancer cells in cervical tissue specimens.
In...
13.2K
Introduction to Statistics01:17

Introduction to Statistics

45.4K
The science of statistics involves collecting, analyzing, interpreting, and presenting data. The method of collecting, organizing, and summarizing data is called descriptive statistics. The systematic method of drawing inferences from the sample data and predicting unknown characteristics of a population is called inferential statistics.
In statistics, the collection of individuals or objects under study is called population. The idea of sampling is to select a portion of the larger population...
45.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Glucocorticoids can induce BIM to trigger apoptosis in the absence of BAX and BAK1.

Cell death & disease·2020
Same author

Cell Death in the Origin and Treatment of Cancer.

Molecular cell·2020
Same author

Targeting triple-negative breast cancers with the Smac-mimetic birinapant.

Cell death and differentiation·2020
Same author

The 2019 Lasker Award: T cells and B cells, whose life and death are essential for function of the immune system.

Cell death and differentiation·2019
Same author

In the absence of apoptosis, myeloid cells arrest when deprived of growth factor, but remain viable by consuming extracellular glucose.

Cell death and differentiation·2019
Same author

Activated MLKL attenuates autophagy following its translocation to intracellular membranes.

Journal of cell science·2019
Same journal

Hidden Messages in Extracellular Vesicles: Cross-Kingdom RNA Communication in Plant and Microbe Interactions.

Annual review of cell and developmental biology·2026
Same journal

mRNA-Scaffolded Cytoplasmic Compartments.

Annual review of cell and developmental biology·2026
Same journal

Developmental Programming of Human Kidney Function.

Annual review of cell and developmental biology·2026
Same journal

The Translation of Genetic Information in Neurodevelopment.

Annual review of cell and developmental biology·2026
Same journal

The Origin and Early Evolution of Fungi: Challenges, Inferences, and Principles.

Annual review of cell and developmental biology·2026
Same journal

Interstitial Spaces: A Basolateral Source of Structure and Signals.

Annual review of cell and developmental biology·2026
See all related articles

Related Experiment Video

Updated: Apr 27, 2026

A Comparative Approach for Quantitative Cell Counting Studies in Widely Different Mammalian Brains
07:14

A Comparative Approach for Quantitative Cell Counting Studies in Widely Different Mammalian Brains

Published on: January 16, 2026

416

Basic statistics in cell biology.

David L Vaux1

  • 1The Walter and Eliza Hall Institute, Parkville, Victoria 3052, Australia.

Annual Review of Cell and Developmental Biology
|July 9, 2014
PubMed
Summary
This summary is machine-generated.

Basic statistics are valuable for cell biologists to improve experimental design, data interpretation, and publication. This review focuses on practical statistical principles for experimental biologists, not complex methods.

Keywords:
error barp-valuereplicatestandard deviationstandard error

More Related Videos

Quantifying Spatiotemporal Parameters of Cellular Exocytosis in Micropatterned Cells
10:21

Quantifying Spatiotemporal Parameters of Cellular Exocytosis in Micropatterned Cells

Published on: September 16, 2020

5.3K
Workflow for High-content, Individual Cell Quantification of Fluorescent Markers from Universal Microscope Data, Supported by Open Source Software
09:57

Workflow for High-content, Individual Cell Quantification of Fluorescent Markers from Universal Microscope Data, Supported by Open Source Software

Published on: December 16, 2014

14.1K

Related Experiment Videos

Last Updated: Apr 27, 2026

A Comparative Approach for Quantitative Cell Counting Studies in Widely Different Mammalian Brains
07:14

A Comparative Approach for Quantitative Cell Counting Studies in Widely Different Mammalian Brains

Published on: January 16, 2026

416
Quantifying Spatiotemporal Parameters of Cellular Exocytosis in Micropatterned Cells
10:21

Quantifying Spatiotemporal Parameters of Cellular Exocytosis in Micropatterned Cells

Published on: September 16, 2020

5.3K
Workflow for High-content, Individual Cell Quantification of Fluorescent Markers from Universal Microscope Data, Supported by Open Source Software
09:57

Workflow for High-content, Individual Cell Quantification of Fluorescent Markers from Universal Microscope Data, Supported by Open Source Software

Published on: December 16, 2014

14.1K

Area of Science:

  • Cell Biology
  • Experimental Biology
  • Scientific Research Methodology

Background:

  • Ernest Rutherford's aphorism highlights the ideal of experiments not needing statistics.
  • However, basic statistical understanding is beneficial for cell biologists in experiment monitoring, result interpretation, and publication.
  • Current statistical training often caters to clinical researchers, not the practical needs of experimental biologists.

Purpose of the Study:

  • To outline fundamental statistical principles relevant to experimental biologists.
  • To provide practical guidance for applying statistics in cell biology research.
  • To bridge the gap between theoretical statistics and the needs of experimental scientists.

Main Methods:

  • Review of basic statistical principles applicable to experimental biology.
  • Focus on practical applications rather than complex statistical models.
  • Exclusion of advanced statistical techniques typically used in clinical research.

Main Results:

  • Identifies key statistical concepts useful for experimental biologists.
  • Emphasizes the importance of statistics in ensuring experimental rigor and accurate data representation.
  • Highlights the need for statistics training tailored to experimental biology.

Conclusions:

  • A foundational grasp of statistics can significantly enhance the quality and impact of cell biology research.
  • This review offers accessible statistical insights for experimental biologists.
  • It advocates for a more practical approach to statistics education in the field.