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Updated: Apr 27, 2026
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Comprehensive Endovascular and Open Surgical Management of Cerebral Arteriovenous Malformations
Published on: October 20, 2017
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Embolization-induced angiogenesis in cerebral arteriovenous malformations
Thomas J Buell1, Dale Ding1, Robert M Starke1
1University of Virginia, Department of Neurosurgery, P.O. Box 800212, Charlottesville, VA 22908, USA.
Summary
Endovascular embolization of cerebral arteriovenous malformations (AVM) can increase angiogenesis, potentially reducing radiosurgery efficacy. This review explores hypoxia, inflammation, and hemodynamics as key mechanisms driving this response.
Area of Science:
- Neurology
- Vascular Biology
- Interventional Radiology
Background:
- Cerebral arteriovenous malformations (AVM) are treated with endovascular occlusion, often combined with radiosurgery or microsurgery.
- Partial embolization of AVMs is linked to increased angiogenesis, which may impair subsequent radiosurgery outcomes.
Purpose of the Study:
- To review the literature and identify potential mechanisms behind embolization-induced angiogenesis in cerebral AVMs.
- To understand how embolization affects AVMs and influences the efficacy of other treatment modalities.
Main Methods:
- A comprehensive literature search was conducted using PubMed.
- Keywords included "arteriovenous malformation", "embolization", and "angiogenesis".
Main Results:
- Three primary mechanisms for embolization-induced angiogenesis were identified: hypoxia-mediated, inflammatory-mediated, and hemodynamic-mediated.
- Cerebral AVM angiogenesis post-embolization likely involves a combination of these mechanisms.
Conclusions:
- Embolization of cerebral AVMs stimulates angiogenesis through multiple pathways.
- Further research is needed to elucidate the specific contribution of each mechanism to AVM neovascularization.
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