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Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases
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Localized abnormalities in the cingulum bundle in patients with schizophrenia: a Diffusion Tensor tractography study.

Thomas J Whitford1, Sun Woo Lee2, Jungsu S Oh3

  • 1School of Psychology, University of New South Wales, Sydney, NSW, Australia ; Psychiatry Neuroimaging Laboratory, Departments of Psychiatry and Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

Neuroimage. Clinical
|July 9, 2014
PubMed
Summary

Schizophrenia patients show altered cingulum bundle (CB) sub-connections. Specific CB pathways (I1 and I4) are linked to positive and negative symptoms, suggesting distinct neurobiological underpinnings for schizophrenia symptoms.

Keywords:
Cingulate gyrusCingulum bundleDTIDiffusion Tensor ImagingFractional AnisotropySchizophrenia

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Area of Science:

  • Neuroimaging
  • Psychiatry
  • Neuroscience

Background:

  • The cingulum bundle (CB) is crucial for limbic system connectivity and implicated in schizophrenia.
  • Emerging evidence suggests the CB comprises multiple distinct sub-connections.

Purpose of the Study:

  • To subdivide the CB into its constituent sub-connections using Diffusion Tensor tractography.
  • To investigate the structural integrity of these sub-connections in schizophrenia patients and healthy controls.

Main Methods:

  • Diffusion Tensor Imaging (DTI) scans were acquired from 24 schizophrenia patients and 26 healthy controls.
  • Deterministic tractography and FreeSurfer-based regions-of-interest were used to define 5 CB sub-connections (I1-I5).

Main Results:

  • Schizophrenia patients exhibited reduced Fractional Anisotropy (FA) in two CB sub-connections: I1 (rostral/caudal anterior cingulate gyrus) and I4 (isthmus cingulate/parahippocampal cortex).
  • FA in I1 correlated with positive symptoms (hallucinations, delusions).
  • FA in I4 correlated with negative symptoms (affective flattening, anhedonia/asociality).

Conclusions:

  • The CB is a complex of distinct sub-connections, with specific pathways showing abnormalities in schizophrenia.
  • Distinct neurobiological underpinnings may exist for positive and negative symptoms of schizophrenia, potentially involving specific CB sub-connections.