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Updated: Apr 27, 2026

Semi-Targeted Ultra-High-Performance Chromatography Coupled to Mass Spectrometry Analysis of Phenolic Metabolites in Plasma of Elderly Adults
Published on: April 22, 2022
Caffeic acid phenethyl ester as a protective agent against nephrotoxicity and/or oxidative kidney damage: a detailed
Sumeyya Akyol1, Veli Ugurcu2, Aynur Altuntas3
1Division of Medical Laboratory Techniques, Vocational School of Health Sciences, Turgut Ozal University, Çeşme Durağı Spor Kompleksi Arkası, Ostim, Yenimahalle, 06370 Ankara, Turkey ; Department of Biochemistry, Medical Faculty, Gaziosmanpasa University, Tokat, Turkey.
Abstract:
Caffeic acid phenethyl ester (CAPE), an active component of propolis, has been attracting the attention of different medical and pharmaceutical disciplines in recent years because of its antioxidant, anti-inflammatory, antiproliferative, cytotoxic, antiviral, antifungal, and antineoplastic properties. One of the most studied organs for the effects of CAPE is the kidney, particularly in the capacity of this ester to decrease the nephrotoxicity induced by several drugs and the oxidative injury after ischemia/reperfusion (I/R). In this review, we summarized and critically evaluated the current knowledge regarding the protective effect of CAPE in nephrotoxicity induced by several special medicines such as cisplatin, doxorubicin, cyclosporine, gentamycin, methotrexate, and other causes leading to oxidative renal injury, namely, I/R models and senility.
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