Related Experiment Video
Updated: Apr 27, 2026
04:42
Developing a Rat Model for Bipolar Disorder
Published on: May 2, 2025
1.7K
Rapid cycling in bipolar disorder: a systematic review
André F Carvalho, Dimos Dimellis1, Xenia Gonda
147-49, Pontou Str, 55133, Kalamaria, Thessaloniki, Greece dimosdimellis@hotmail.com.
The Journal of Clinical Psychiatry
|July 9, 2014
Summary
Rapid cycling bipolar disorder is a frequent, worsening condition associated with poorer outcomes. Early recognition improves treatment strategies for this underrecognized aspect of bipolar disorder.
Area of Science:
- Psychiatry
- Neuroscience
- Clinical Psychology
Background:
- Bipolar disorder is characterized by recurring mood episodes.
- Rapid cycling bipolar disorder involves at least 4 mood episodes within 12 months.
- Understanding rapid cycling is crucial for managing bipolar disorder's long-term course.
Purpose of the Study:
- To synthesize data on the prevalence of rapid cycling bipolar disorder.
- To explore clinical correlates, including familial and genetic aspects.
- To provide a comprehensive overview of rapid cycling in bipolar disorder.
Main Methods:
- Systematic review of MEDLINE database up to September 2013.
- Searched using keywords 'rapid cycling' and 'rapid-cycling'.
- Included 119 original studies meeting DSM criteria for rapid cycling bipolar disorder.
Main Results:
- Rapid cycling affects 5%-33.3% (yearly) and 25.8%-43% (lifetime) of bipolar patients.
- Associated with earlier onset, longer illness duration, substance abuse, and increased suicidality.
- Etiology unclear; antidepressants and hypothyroidism implicated; appears transitory, not a stable subtype.
Conclusions:
- Rapid cycling is a frequent, underrecognized worsening of bipolar disorder.
- Early recognition is key for improved treatment and long-term outcomes.
- Conceptualizing rapid cycling via Research Domain Criteria is a future advance.
More Related Videos
Related Concept Videos
01:30Bipolar Disorder
1.4K
Bipolar disorder is a chronic mental health condition marked by significant mood fluctuations, including episodes of mania and depression. Elevated energy levels, heightened mood or irritability, impulsive behavior, reduced sleep needs, rapid speech, racing thoughts, inflated self-esteem, and distractibility characterize mania. Individuals with bipolar disorder often alternate between depressive and manic states, with periods of emotional stability lasting an average of six months to a year.
1.4K
01:24Mania and Antimanic Drugs: Overview
791
Mania, a psychological condition characterized by elevated mood, increased energy, and reduced sleep need, is part of the bipolar disorder cycle. The exact cause of mania isn't entirely known, but it is thought to be a combination of genetic, environmental, and neurological factors. Bipolar disorder involves alternating manic and depressive episodes. Mood stabilizers like lithium, antipsychotics, and anticonvulsants help manage these episodes. Lithium carbonate is particularly effective as...
791
01:26Psychosis: Goals of Pharmacotherapy
699
Antipsychotic drugs are a crucial treatment method for acute and chronic psychoses, bipolar illness, and behavioral disorders. The selection of these drugs depends on several factors, including the state of the disease, clinical judgment, possible drug interactions, and the patient's sensitivity to adverse effects. In immediate scenarios, such as delirium and dementia, short-term treatment with low doses of high-potency typical or atypical agents can effectively manage symptom exacerbation.
699
01:28Psychosis and Antipsychotic Drugs: Overview
1.2K
The term "psychosis" refers to a spectrum of mental disorders characterized by abnormal thoughts, perceptions, and behaviors. It can manifest as mood disorders, dementia, delirium with psychotic features, substance-induced psychosis with psychotic features, brief psychotic disorder, delusional disorder, schizoaffective disorder, and schizophrenia. Among all these disorders, schizophrenia is the most common psychotic disorder, affecting 1% of the worldwide population. Psychotic...
1.2K
01:25Borderline Personality Disorder
1.1K
Borderline Personality Disorder is a complex and multifaceted mental health condition characterized by pervasive instability in interpersonal relationships, self-image, emotions, and impulse control. This instability manifests in extreme emotional reactions, fear of abandonment, and self-destructive behaviors. The disorder significantly impacts daily functioning, often leading to distress in both personal and professional domains.
Genetic and Environmental Contributions
Borderline Personality...
Genetic and Environmental Contributions
Borderline Personality...
1.1K
01:29Dysrhythmias III: Characteristics of Dysrhythmias
703
Dysrhythmias, also known as arrhythmias, are irregular heart rhythms that result from abnormal electrical activity in the heart, affecting its ability to circulate blood efficiently. Tachyarrhythmias, a subset of dysrhythmias, are characterized by abnormally fast heart rates exceeding 100 beats per minute. Here are some types of tachyarrhythmias with their distinct ECG features:Sinus Tachycardia:Sinus tachycardia presents a regular heart rhythm with an increased rate of 101-180 beats per...
703