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Antidiuretic responses to osmotic cutaneous stimulation in the toad, Bufo arenarum. A possible adaptive control
S Petriella1, J C Reboreda, M Otero
1Laboratorio de Fisiologia del Comportamiento, Instituto de Biologia y Medicina Experimental, Buenos Aires, Argentina.
Abstract:
Osmotic stimulation of the skin of the toad Bufo arenarum with isotonic (115 mM) or hypertonic (400 mM) NaCl solutions produced a marked and reversible antidiuresis within 5 min. No changes in plasma osmolarity were detected in the course of this response. Hypophysectomized animals exhibited a lower and delayed antidiuresis when exposed to a hypertonic environment (400 mM NaCl). This antidiuretic response was drastically reduced in normal toads after ten consecutive days of administration of the sympatoplexic guanethidine. The existence of a feed-forward control of urine production initiated by cutaneous osmotic sensors and involving an adrenergic component is proposed.
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