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Co-existence of familial Mediterranean fever and multiple sclerosis in two patients

G Ceylan, S Erten, K Ercan

    Acta Reumatologica Portuguesa
    |July 10, 2014
    PubMed

    Insights

    Familial Mediterranean fever (FMF) and multiple sclerosis (MS) can co-occur. Genetic analysis revealed M694V mutations in two young female patients diagnosed with both FMF and MS, highlighting a rare but possible comorbidity.

    Area of Science:

    • Neurology
    • Immunology
    • Genetics

    Background:

    • Familial Mediterranean fever (FMF) is a genetic autoinflammatory disorder.
    • Multiple sclerosis (MS) is a chronic autoimmune disease affecting the central nervous system.
    • The co-occurrence of FMF and MS is exceptionally rare.

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