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IgA deficiency, autoimmunity & pregnancy: a population-based matched cohort study.
Jonas F Ludvigsson1, Martin Neovius, Olof Stephansson
1Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Box 281, 171 77, Stockholm, Sweden, jonasludvigsson@yahoo.com.
Journal of Clinical Immunology
|July 10, 2014
Summary
Women with immunoglobulin A (IgA) deficiency have a slightly increased risk of adverse pregnancy outcomes, including lower birth weight and smaller for gestational age infants. These risks are reduced when autoimmune diseases are not present.
Area of Science:
- Reproductive immunology
- Perinatal outcomes
- Autoimmune disorders
Background:
- Autoimmune disorders are linked to adverse pregnancy outcomes.
- Immunoglobulin A (IgA) deficiency shares autoimmune traits, but its association with pregnancy outcomes is not well understood.
Purpose of the Study:
- To investigate the association between IgA deficiency and adverse pregnancy and perinatal outcomes.
- To determine if autoimmune diseases influence this association.
Main Methods:
- A prospective, population-based cohort study in Sweden.
- Included 613 mothers with IgA deficiency and 5,758 matched controls.
- Infant outcomes were registered in the Swedish Medical Birth Register.
Main Results:
- Offspring of mothers with IgA deficiency had lower birth weight and shorter gestational age.
- Increased risk of small for gestational age births and cesarean sections.
- No difference in preterm birth or low Apgar scores.
- Excess risks diminished when excluding women with autoimmune diseases.
Conclusions:
- Women with IgA deficiency face a small excess risk of certain adverse delivery and perinatal outcomes.
- The presence of autoimmune diseases attenuates these excess risks.
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