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Sequence-specific Labeling of Nucleic Acids and Proteins with Methyltransferases and Cofactor Analogues
12:07

Sequence-specific Labeling of Nucleic Acids and Proteins with Methyltransferases and Cofactor Analogues

Published on: November 22, 2014

Monoadduct forming photochemical reagents for labeling nucleic acids for hybridization

J P Albarella1, R L Minegar, W L Patterson

  • 1Miles Inc., Elkhart, IN 46515.

Nucleic Acids Research
|June 12, 1989
PubMed

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In situ hybridization (ISH) is a technique used to detect and localize specific DNA or RNA molecules in cells, tissue, or tissue sections using a labeled probe. The technique was first used in 1969 for the investigation of nucleic acids. It is currently an essential tool in scientific research and clinical settings, especially for diagnostic purposes.
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