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Updated: Apr 27, 2026

Biosynthesis of a Flavonol from a Flavanone by Establishing a One-pot Bienzymatic Cascade
Published on: August 14, 2019
Synthesis of riboflavines, quinoxalinones and benzodiazepines through chemoselective flow based hydrogenations
Marcus Baumann1, Ian R Baxendale2, Christian H Hornung3
1Department of Chemistry, University of Durham, South Road, Durham DH1 3LE, UK.
Abstract:
Robust chemical routes towards valuable bioactive entities such as riboflavines, quinoxalinones and benzodiazepines are described. These make use of modern flow hydrogenation protocols enabling the chemoselective reduction of nitro group containing building blocks in order to rapidly generate the desired amine intermediates in situ. In order to exploit the benefits of continuous processing the individual steps were transformed into a telescoped flow process delivering selected benzodiazepine products on scales of 50 mmol and 120 mmol respectively.
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