Related Experiment Video
Updated: Aug 18, 2026

HPLC-based Assay to Monitor Extracellular Nucleotide/Nucleoside Metabolism in Human Chronic Lymphocytic Leukemia Cells
Published on: July 20, 2016
[The character of quantitative changes in some parameters of polyamine metabolism of the blood in patients with
Abstract:
Content of polyamines and some patterns of metabolism related to their synthesis and catabolism were studied in blood of patients with chronic myeloleukemia and chronic lympholeukemia. Free polyamines as well as activity of diamine oxidase were distinctly increased in blood, while concentration of total diamino acids was simultaneously decreased in blood serum of the patients as compared with that of healthy persons. Specific type of the quantitative alterations was responsible for efficiency of chemotherapy in these patients.
Related Concept Videos
Nonlinear Pharmacokinetics: Dependence of Elimination Half-Life and Dose Clearance
A study on guinea pigs examined the...
Effect of Hepatic Disease on Pharmacokinetics: Pathophysiologic Assessment and Liver Function Test

