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Genome wide association scan for chronic periodontitis implicates novel locus
Ping Feng, Xiaojing Wang, Priscila L Casado
1Department of Oral Biology, School of Dental Medicine, University of Pittsburgh, 3501 Terrace Street, Pittsburgh, PA 15261, USA. arv11@pitt.edu.
BMC Oral Health
|July 11, 2014
Summary
Genetic factors contribute to chronic periodontitis. A genome-wide association study identified a potential risk locus on chromosome 16q22.3, suggesting a protective role for a less common allele.
Area of Science:
- Genetics
- Periodontology
- Genomics
Background:
- Chronic periodontitis has a known genetic component.
- This study investigated genetic associations in a cohort from the University of Pittsburgh Dental Registry and DNA Repository.
Purpose of the Study:
- To conduct a genome-wide association study (GWAS) to identify genetic variants associated with chronic periodontitis.
- To validate potential findings in independent datasets.
Main Methods:
- Genotyping of over 500,000 single nucleotide polymorphisms (SNPs) in 866 participants.
- Analysis of complete dataset and self-reported White samples, followed by testing in Brazilian cohorts.
- Meta-analysis of SNPs showing association trends.
Main Results:
- The rs1477403 marker on 16q22.3 showed suggestive association in discovery and Porto Alegre datasets (p=0.05).
- Meta-analysis indicated that the less common allele of rs1477403 may decrease the risk of chronic periodontitis.
Conclusions:
- The 16q22.3 locus presents a promising candidate for further investigation in chronic periodontitis.
- This study provides a hypothesis for the genetic contribution of 16q22.3 to periodontitis risk.
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