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[Relationship between resting heart rate and carotid artery structure in young hypertensive patients]
Jianghong Song1, Yuanming Zhang2, Chao Zhang1
1Department of Outpatient, 69010 Unit PLA, Urumqi 830011, China.
Insights
In young hypertensive patients, higher resting heart rate (RHR) is linked to increased blood pressure and decreased carotid artery diameter. This suggests RHR may indicate cardiovascular risk in this population.
Area of Science:
- Cardiovascular Medicine
- Hypertension Research
- Vascular Biology
Context:
- Young adults with primary hypertension present unique challenges in cardiovascular risk assessment.
- Resting heart rate (RHR) is a readily measurable physiological parameter.
- Carotid artery structure, assessed via intima-media thickness and diameter, is a marker of subclinical atherosclerosis.
Purpose:
- To examine the association between resting heart rate (RHR) and carotid artery structural parameters in young hypertensive individuals.
- To determine if RHR correlates with blood pressure and carotid artery dimensions in this demographic.
Summary:
- A study of 663 young hypertensive patients (18-45 years) categorized RHR into three groups.
- Carotid artery intima-media thickness and diameter were measured using ultrasonography.
- Results indicated significant positive correlations between RHR and blood pressure, and a negative correlation between RHR and left carotid artery diameter.
Impact:
- Findings suggest that elevated RHR in young hypertensive patients may be associated with adverse vascular changes.
- This highlights RHR as a potential indicator for cardiovascular risk stratification in this population.
- Further research could explore RHR as a target for intervention to improve vascular health in young hypertensives.
Objective:
To investigate the relationship between resting heart rate (RHR) and carotid artery structure in young hypertensive patients.
Methods:
A total of 663 primary hypertensive patients aged between 18 and 45 (38.01 ± 5.78) were chosen from the First Affiliated Hospital of Xinjiang Medical University from January, 2009 to January, 2012. Patients under this study were divided into three groups according to their RHRs: group A (RHR<70 bpm, n = 163), group B (70 bpm≤RHR<80 bpm, n = 268), group C (RHR≥80 bpm, n = 232). Data on bilateral carotid artery intima-media thickness, common carotid artery diameter were detected by carotid ultra- sonography. Indexes of carotid artery were analyzed by both variance and bi-variate correlation analysis.
Results:
1) Differences in the blood pressure among three groups showed statistical significance (P < 0.01), with diastolic pressure in group A higher than in group B (P < 0.05), while both systolic and diastolic pressure in group C higher than in group B (P < 0.01). 2) In group A, the right carotid artery diameter was higher than in group C (P < 0.05) and the left carotid artery diameter higher than in group B (P < 0.05) with the left carotid artery diameter higher than in group C (P < 0.05). 3) Significant positive correlations were found between RHR and blood pressure (r = 0.112,0.118) and negative correlation between RHR and left carotid artery diameter (r = -0.89). However, correlation between RHR and right carotid artery diameter was not significant (r = -0.075, P = 0.068).
Conclusion:
When blood pressure had an increase, we found that the carotid artery diameter was decreasing along with the increasing RHR among the young hypertensive patients.
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