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Monocular Visual Deprivation and Ocular Dominance Plasticity Measurement in the Mouse Primary Visual Cortex

Monocular Visual Deprivation and Ocular Dominance Plasticity Measurement in the Mouse Primary Visual Cortex

Published on: February 8, 2020

Orientation-tuned surround suppression in mouse visual cortex.

Matthew W Self¹, Jeannette A M Lorteije², Joris Vangeneugden²

¹Department of Vision and Cognition, m.self@nin.knaw.nl.

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience

|July 11, 2014

Summary

This summary is machine-generated.

Neurons in mouse primary visual cortex (V1) exhibit orientation-dependent surround suppression, a key visual processing mechanism. This orientation tuning in V1 layer 4 is independent of superficial layers, revealing distinct neural pathways.

Keywords:

V1 laminar mouse visual cortex orientation scene segmentation surround suppression

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Area of Science:

Neuroscience
Visual Neuroscience
Cortical Circuitry

Background:

Surround suppression in primary visual cortex (V1) modulates neural responses based on stimulus size.
In primates, this suppression is orientation-tuned, aiding scene segmentation but with poorly understood mechanisms.
Investigating mouse V1 is crucial due to technological advancements in studying cortical circuits.

Purpose of the Study:

To determine if mouse V1 neurons exhibit orientation-tuned surround suppression.
To investigate the neural mechanisms underlying orientation-dependent surround suppression in mouse V1.
To explore the role of different V1 layers and their interdependencies in this phenomenon.

Main Methods:

Electrophysiological recordings in mouse V1 to measure neuronal firing rates.
Presentation of stimuli with varying orientations (iso-oriented vs. cross-oriented surrounds).
Layer-specific analysis of surround suppression and application of lidocaine to silence superficial layers.

Main Results:

Mouse V1 neurons display robust surround suppression, particularly in layer 4 and superficial layers.
Surround suppression in mouse V1 is orientation-tuned, with iso-oriented surrounds causing greater suppression.
Orientation-tuned suppression in layer 4 persists even when superficial layers are silenced.

Conclusions:

Mouse V1 exhibits orientation-dependent surround suppression, similar to primates, despite lacking orientation columns.
Two distinct suppressive mechanisms are suggested by the temporal dynamics of surround suppression.
Layer 4's orientation-tuned surround suppression is independent of superficial layer contributions.