Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Epigenetic Regulation of the NET Formation-Blood-Brain Barrier Axis in Ischemic Stroke: Mechanisms, Therapeutic Targets and Translational Perspectives.

Neurology international·2026
Same author

A Roadmap to Navigate the Future of Neural Engineering.

Journal of neural engineering·2026
Same author

How the visual brain can learn to parse images using a multiscale, incremental grouping process.

PLoS computational biology·2026
Same author

Friend, not Foe: Lowered Tissue Reactivity to Long-Term Polyimide Implants.

bioRxiv : the preprint server for biology·2026
Same author

Targeted degradation of MK2 is insufficient to block inflammatory cytokine production in human cells due to cooperativity with MK3 and MK5.

Frontiers in immunology·2026
Same author

Contemporary trends on the kinase inhibitors with special reference to quinoxaline derivatives.

Molecular diversity·2025
Same journal

Retinomorphic Visual Processing Enabled by Contact-Engineered IGZO Optoelectronic Synaptic Memtransistors.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2026
Same journal

Optical Windows for Transcranial Brain Imaging in Living Mice: Skull Thinning, Clearing, and Beyond.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2026
Same journal

Synergistic Interface Engineering via Buffer Layer and UVO Treatment for High-Performance PbS Quantum Dot Near-Infrared Photodiodes.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2026
Same journal

Strain-Adaptive Dielectric Metamaterials via Bioinspired "Ligament-Bone" Architecture for Ultrahigh-Energy Capacitive Storage.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2026
Same journal

Tailoring K<sup>+</sup> Dosage in K<sup>+</sup>/Zn<sup>2+</sup> Mixed Electrolytes via Lattice Expansion Regulation of Zinc Hexacyanoferrate for High-performance Zinc Ion Batteries.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2026
Same journal

Super-Resolution and High-Data-Density Acoustic Meta-Hologram via Amplitude and Phase Coupling.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2026
See all related articles
  1. Home
  3. Friend, Not Foe: Lowered Tissue Reactivity To Long-term Polyimide Implants.
  1. Home
  3. Friend, Not Foe: Lowered Tissue Reactivity To Long-term Polyimide Implants.

Related Experiment Video

Environmental Dynamic Mechanical Analysis to Predict the Softening Behavior of Neural Implants
06:59

Environmental Dynamic Mechanical Analysis to Predict the Softening Behavior of Neural Implants

Published on: March 1, 2019

8.5K

Friend, Not Foe: Lowered Tissue Reactivity to Long-Term Polyimide Implants.

Corinne Orlemann1, Laura M De Santis1, Paul Neering1

  • 1Department of Vision and Cognition, Netherlands Institute for Neuroscience, Amsterdam, Netherlands.

Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
|April 15, 2026

View abstract on PubMed

Summary
This summary is machine-generated.

Flexible polyimide probes significantly reduce brain tissue damage and inflammation compared to stiff silicon probes. This research offers key insights for designing better neurotechnologies and improving surgical integration of intracortical electrode arrays.

Keywords:
biocompatibilityforeign body responsehistologyintracortical electrodesneurotechnology

More Related Videos

Chronic Implantation of Multiple Flexible Polymer Electrode Arrays
08:54

Chronic Implantation of Multiple Flexible Polymer Electrode Arrays

Published on: October 4, 2019

11.6K
Tools for Surface Treatment of Silicon Planar Intracortical Microelectrodes
06:39

Tools for Surface Treatment of Silicon Planar Intracortical Microelectrodes

Published on: June 8, 2022

2.9K

Related Experiment Videos

Environmental Dynamic Mechanical Analysis to Predict the Softening Behavior of Neural Implants
06:59

Environmental Dynamic Mechanical Analysis to Predict the Softening Behavior of Neural Implants

Published on: March 1, 2019

8.5K
Chronic Implantation of Multiple Flexible Polymer Electrode Arrays
08:54

Chronic Implantation of Multiple Flexible Polymer Electrode Arrays

Published on: October 4, 2019

11.6K
Tools for Surface Treatment of Silicon Planar Intracortical Microelectrodes
06:39

Tools for Surface Treatment of Silicon Planar Intracortical Microelectrodes

Published on: June 8, 2022

2.9K

Area of Science:

  • Neuroscience
  • Biomaterials Science
  • Medical Device Engineering

Background:

  • Designing neurotechnology requires balancing device functionality and brain tissue compatibility.
  • Minimizing tissue damage and inflammation is crucial for long-term performance of neural implants.

Purpose of the Study:

  • To systematically evaluate how probe design parameters influence tissue response in the mouse cerebral cortex.
  • To identify design features that mitigate damage and enhance the longevity of neural implants.

Main Methods:

  • Implanted 103 stiff silicon and flexible polyimide probes of varying dimensions in 32 mice.
  • Quantified tissue loss, neuronal density, and glial immune response (astrocytic and microglial) using an automated immunohistochemical analysis workflow.
  • Examined immune reactivity across cortical depth.

Main Results:

  • Flexible polyimide probes demonstrated significantly less tissue damage and weaker immune responses compared to stiff silicon probes.
  • Probe shank cross-section had a minimal impact on tissue reaction.
  • Immune reactivity was concentrated at superficial cortical entry points and the cortex-white matter boundary.

Conclusions:

  • Flexible polyimide probes are superior to stiff silicon probes for neural implantation due to reduced tissue damage and inflammation.
  • Optimized device design parameters and surgical techniques are essential for improved tissue integration of intracortical electrode arrays.
  • Understanding cortical depth-dependent immune responses informs future neurotechnology development.