Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Urinary Tract Infection II: Pathophysiology01:25

Urinary Tract Infection II: Pathophysiology

1.4K
The pathophysiology of urinary tract infections (UTIs) encompasses several progressive stages, beginning with bacterial colonization and culminating in potential systemic complications if untreated. UTIs are primarily initiated by bacteria, such as Escherichia coli, which often originate from the gastrointestinal tract and migrate to the urinary system through the periurethral area. This migration can occur via several routes, including improper hygiene practices, sexual activity, or...
1.4K
Urinary Bladder01:23

Urinary Bladder

4.6K
The urinary bladder is a hollow, muscular sac that temporarily stores urine before it is expelled from the body. It can hold approximately 600 mL of urine prior to micturition. The bladder is retroperitoneal and located behind the pubic symphysis in the pelvic floor.
In males, the bladder is situated in front of the rectum, while in females, it is positioned anterior to the vagina and uterus. The bladder floor contains an inverted triangular area called the trigone, defined by the two ureteric...
4.6K
Disorders of the Urinary System01:20

Disorders of the Urinary System

2.1K
The urinary system is responsible for eliminating waste and excess fluids from the body. However, disorders of the urinary system can arise due to various reasons like infections, stress, age, congenital abnormalities, and lifestyle.
Urinary tract infections (UTIs) are one of the most common urinary system disorders. They are caused by bacteria that enter the urethra and can spread to the bladder resulting in cystitis. Pyelonephritis is the result of a UTI that has ascended to the level of the...
2.1K
Anatomy of the Genitourinary System II: Bladder and Urethra01:19

Anatomy of the Genitourinary System II: Bladder and Urethra

3.6K
The lower urinary system consists of the urinary bladder and urethra, which are essential in storing and expelling urine from the body. Together with the internal and external sphincters, these structures work together to regulate urination effectively.Anatomy of the BladderThe urinary bladder is a muscular, stretchable organ behind the pubic bone and in front of the rectum. In females, the bladder is positioned anterior to the vagina and inferior to the uterus, while in males, it is located...
3.6K
Acute Kidney Injury II: Pathophysiology01:29

Acute Kidney Injury II: Pathophysiology

2.2K
Acute kidney injury (AKI) causes are categorized into three primary categories based on the location of the injury: prerenal, intrarenal (or intrinsic), and postrenal causes. This classification guides clinical management and illustrates how different pathways can impair kidney function.Etiology and Pathophysiology of Acute Kidney Injury1. Prerenal causesEtiology: Prerenal Acute Kidney Injury, the most common type, occurs when reduced blood flow to the kidneys decreases filtration capacity...
2.2K
Urinary Tract Calculi II: Pathophysiology and Clinical Manifestations01:26

Urinary Tract Calculi II: Pathophysiology and Clinical Manifestations

810
Renal calculi, commonly termed kidney stones, are crystalline solid masses that form in the kidneys but can occur at any point within the urinary system, encompassing the kidneys, ureters, bladder, and urethra.The pathophysiology of renal stones involves several key factors: supersaturation of the urine with stone-forming constituents, changes in urine pH, a decrease in urine volume, and the presence of substances that promote or inhibit stone formation.Supersaturation of Urine: This is the...
810

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Integrative mechanisms and intervention targets of the microbiota-gut-brain axis in depressive disorders: advances across immune, endocrine, and central nervous system pathways.

Frontiers in psychiatry·2026
Same author

ATP13A2 promoted cell stemness, cisplatin resistance, autophagy, and cell progression of bladder cancer.

Frontiers in immunology·2026
Same author

Efficacy and Safety of Yinhua Miyanling Tablets for Uncomplicated Urinary Tract Infections: A Multicenter, Randomized, Double-Blind, Double-Dummy, Active-Controlled, Non-inferiority Clinical Trial.

Chinese journal of integrative medicine·2026
Same author

A positive SPTBN2-FLI1 feedback axis promotes bladder cancer via PI3K/AKT activation.

Cellular signalling·2026
Same author

COMMD4 Drives Skin Cutaneous Melanoma Progression by Targeting PI3K-p85 to Activate PI3K-AKT.

Annals of the New York Academy of Sciences·2025
Same author

Room-Temperature Ferroelectricity of Bi<sub>2</sub>O<sub>2</sub>Se in the Two-Dimensional Limit.

Nano letters·2025

Related Experiment Video

Updated: Apr 27, 2026

A Decentralized Ex Vivo Murine Bladder Model with the Detrusor Muscle Removed for Direct Access to the Suburothelium during Bladder Filling
06:36

A Decentralized Ex Vivo Murine Bladder Model with the Detrusor Muscle Removed for Direct Access to the Suburothelium during Bladder Filling

Published on: November 28, 2019

6.3K

[Bladder interstitial cells and pathophysiology].

Zhuo Yin1, Jinrui Yang

  • 1Department of Urology Surgery, Second Xiangya Hospital, Central South University, Changsha 410011, China.

Zhong Nan Da Xue Xue Bao. Yi Xue Ban = Journal of Central South University. Medical Sciences
|July 12, 2014
PubMed
Summary
This summary is machine-generated.

Bladder interstitial cells (IC) are crucial for bladder function, with distinct subtypes and signaling pathways. Lesions affecting these pathways can cause bladder dysfunction, but treatments like imatinib mesylate and acupuncture show promise.

More Related Videos

Expression of Transgenes in Native Bladder Urothelium Using Adenovirus-Mediated Transduction
06:01

Expression of Transgenes in Native Bladder Urothelium Using Adenovirus-Mediated Transduction

Published on: October 6, 2022

1.3K
Transurethral Instillation Procedure in Adult Male Mouse
04:01

Transurethral Instillation Procedure in Adult Male Mouse

Published on: November 2, 2017

16.7K

Related Experiment Videos

Last Updated: Apr 27, 2026

A Decentralized Ex Vivo Murine Bladder Model with the Detrusor Muscle Removed for Direct Access to the Suburothelium during Bladder Filling
06:36

A Decentralized Ex Vivo Murine Bladder Model with the Detrusor Muscle Removed for Direct Access to the Suburothelium during Bladder Filling

Published on: November 28, 2019

6.3K
Expression of Transgenes in Native Bladder Urothelium Using Adenovirus-Mediated Transduction
06:01

Expression of Transgenes in Native Bladder Urothelium Using Adenovirus-Mediated Transduction

Published on: October 6, 2022

1.3K
Transurethral Instillation Procedure in Adult Male Mouse
04:01

Transurethral Instillation Procedure in Adult Male Mouse

Published on: November 2, 2017

16.7K

Area of Science:

  • Urology
  • Cell Biology
  • Physiology

Background:

  • Bladder interstitial cells (IC) are specialized cells integral to bladder function.
  • IC possess unique ultrastructural features, including an incomplete basement membrane and distinct organelle content.
  • Four IC subtypes exist: lamina propria, intramuscular, inter-detrusor, and perivascular.

Purpose of the Study:

  • To elucidate the role of bladder interstitial cells (IC) in bladder function and dysfunction.
  • To explore the specific ion currents and Ca2+ signaling pathways in different IC subtypes.
  • To identify potential therapeutic targets for bladder disorders linked to IC dysfunction.

Main Methods:

  • Characterization of bladder interstitial cell (IC) ultrastructure.
  • Analysis of ion currents and activation pathways in lamina propria and intramuscular IC.
  • Investigation of Ca2+ signaling in IC-detrusor communication.

Main Results:

  • Bladder interstitial cells (IC) exhibit diverse subtypes with distinct electrophysiological properties.
  • Calcium (Ca2+) signaling pathways are vital for communication between IC and detrusor smooth muscle.
  • Bladder dysfunctions are associated with disruptions in IC ion currents and Ca2+ signaling.

Conclusions:

  • Bladder interstitial cells (IC) and their associated signaling pathways are critical for maintaining normal bladder function.
  • Dysregulation of IC ion and Ca2+ signaling underlies various bladder pathologies, including bladder outlet obstruction, bladder pain syndrome, interstitial cystitis, neurogenic bladder, and diabetes.
  • Imatinib mesylate and electrical stimulation acupuncture therapy represent potential therapeutic strategies for IC-related bladder dysfunction.