Related Experiment Video
Updated: Apr 27, 2026
Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty
Published on: January 28, 2020
Time-dependent changes of plasma adiponectin concentration in relation to coronary microcirculatory function in
Danijela Trifunovic1, Sanja Stankovic2, Jelena Marinkovic3
1Department of Cardiology, Clinical Centre of Serbia, Belgrade, Serbia; School of Medicine, University of Belgrade, Belgrade, Serbia.
Insights
Plasma adiponectin levels after ST-segment elevation myocardial infarction (STEMI) treatment correlate with coronary microcirculation function. Low adiponectin, particularly early after percutaneous coronary intervention (pPCI), indicates a risk for impaired coronary flow reserve (CFR).
Area of Science:
- Cardiology
- Biochemistry
- Internal Medicine
Background:
- ST-segment elevation myocardial infarction (STEMI) is a critical cardiovascular event.
- Coronary microcirculation plays a vital role in myocardial recovery post-STEMI.
- Adiponectin, a hormone, is implicated in cardiovascular health and inflammation.
Purpose of the Study:
- To investigate plasma adiponectin kinetics in STEMI patients undergoing primary percutaneous coronary intervention (pPCI).
- To assess the association between adiponectin levels and coronary flow reserve (CFR), a marker of microcirculatory function.
- To determine if adiponectin levels predict impaired CFR post-STEMI.
Main Methods:
- Ninety-six STEMI patients treated with pPCI were studied.
- Plasma adiponectin was measured on admission, and on days 2 and 7 post-pPCI.
- Coronary flow reserve (CFR) was assessed on day 7 post-pPCI.
Main Results:
- Adiponectin levels peaked on admission, dropped by day 2, and partially recovered by day 7.
- Forty-one percent of patients exhibited impaired CFR (CFR<2).
- Adiponectin concentrations positively correlated with CFR, with the strongest association observed on day 2 (r=0.489, p<0.001). Adiponectin levels were independent predictors of impaired CFR.
Conclusions:
- Plasma adiponectin levels before and after pPCI are significantly associated with CFR in STEMI patients.
- Lower adiponectin levels, especially in the early post-pPCI phase, are linked to impaired coronary microcirculatory function.
- Adiponectin may serve as a valuable biomarker for assessing microvascular function after STEMI.
Background And Purpose:
To analyze plasma adiponectin kinetics in patients with ST-segment elevation myocardial infarction (STEMI) treated by primary percutaneous coronary intervention (pPCI) and its association with coronary flow reserve (CFR), an index of coronary microcirculatory function.
Methods:
A total of 96 consecutive patients with the first anterior STEMI treated by pPCI without heart failure were included. CFR was assessed on the 7th day after pPCI. Plasma adiponectin was measured on admission before pPCI, and on the 2nd and 7th day after pPCI.
Results:
Adiponectin concentration was the highest on admission, declined to the lowest level on the 2nd day, and rose on the 7th day remaining below admission values. Impaired coronary microcirculatory function (CFR<2) was observed in 41% of the patients. Adiponectin concentrations significantly positively correlated with CFR, and the strongest correlation was with the 2nd day adiponectin (r=0.489, p<0.001). In multivariate models, adiponectin concentrations were independent predictors of impaired CFR [on admission: odds ratio (OR) 0.175, confidence interval (CI): 0.047-0.654, p=0.010; 2nd day: OR 0.146, 95% CI: 0.044-0.485, p=0.002; 7th day: OR 0.198, CI: 0.064-0.611, p=0.005]. The best power to predict impaired CFR was the 2nd day adiponectin. Delta values of adiponectin (differences between adiponectin concentrations) did not correlate with CFR.
Conclusions:
In patients with the first anterior STEMI treated by pPCI plasma adiponectin concentrations before and after pPCI are strongly associated with CFR. Our results support the hypothesis that low adiponectin, especially during the early post-pPCI period, carries the risk for impaired coronary microcirculatory function in STEMI patients.
More Related Videos
04:41Digital PCR for Quantifying Circulating MicroRNAs in Acute Myocardial Infarction and Cardiovascular Disease
Published on: July 3, 2018
07:25Predicting Amputation using Local Circulating Mononuclear Progenitor Cells in Angioplasty-treated Patients with Critical Limb Ischemia
Published on: September 22, 2020
Related Concept Videos
01:20Blood Studies for Cardiovascular System I: Cardiac Biomarkers
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
01:28Acute Coronary Syndrome IV: Interprofessional Care
01:19Acute Coronary Syndrome II: Pathophysiology and Clinical Manifestations