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Related Experiment Video

Updated: Apr 27, 2026

Retinal Pigment Epithelium Transplantation in a Non-human Primate Model for Degenerative Retinal Diseases
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[Proliferative vitreoretinopathy: prophylactic treatment].

C Chiquet1, F Rouberol2

  • 1Clinique universitaire d'ophtalmologie, université J.-Fourier, CHU de Grenoble, BP 217, 38043 Grenoble cedex 09, France.

Journal Francais D'Ophtalmologie
|July 12, 2014
PubMed
Summary

Proliferative vitreoretinopathy (PVR) is a severe complication of retinal detachment (RD) causing surgical failure. Early antiproliferative treatment, like 5-fluoro-uracil and heparin, can reduce postoperative PVR onset in high-risk patients.

Keywords:
5-fluoro-uracilCorticosteroidsCorticoïdeDaunomycinDaunomycineDécollement de rétineHeparinHéparinePreventionProliferative vitreoretinopathyProlifération vitréo-rétiniennePréventionRetinal detachment

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Area of Science:

  • Ophthalmology
  • Retinal Diseases
  • Vitreoretinal Surgery

Context:

  • Proliferative vitreoretinopathy (PVR) is a major cause of surgical failure following rhegmatogenous retinal detachment (RD).
  • PVR involves contractile fibrocellular membranes that impede retinal reattachment, leading to poor anatomic and functional outcomes.
  • Current incidence of PVR is 5-11%, contributing significantly to the 50-75% surgical failure rate in RD cases.

Purpose:

  • To highlight the significance of PVR as a complication of RD.
  • To emphasize the need for risk factor identification and tailored surgical approaches.
  • To underscore the importance of early antiproliferative treatment strategies.

Summary:

  • PVR is a complex condition complicating RD, characterized by membrane formation that hinders retinal reattachment.
  • Identifying patients at risk through clinical factors (tear characteristics, detachment extent) and biological markers is crucial for prevention.
  • Combining 5-fluoro-uracil and heparin during vitrectomy infusion has shown promise in reducing postoperative PVR in at-risk individuals.

Impact:

  • Early identification of PVR risk factors allows for surgical approach adaptation.
  • Antiproliferative treatments, such as 5-fluoro-uracil and heparin, can decrease the incidence of postoperative PVR.
  • Further research into novel molecules and dosages is essential for advancing PVR treatment and improving patient prognosis.