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Tight Junctions

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Tight junctions are molecular seals between cells that prevent the leaking of fluids, ions, and other small solutes across cavities and compartments in multicellular organisms. They are mainly composed of claudin and occludin transmembrane proteins, and other proteins such as tricellulin and JAM (junctional adhesion molecule). All these proteins are 4-pass transmembrane proteins, except JAM, which is a single-pass transmembrane protein belonging to the immunoglobulin superfamily. The...

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Related Experiment Video

Updated: Apr 27, 2026

Functional Assessment of Intestinal Tight Junction Barrier and Ion Permeability in Native Tissue by Ussing Chamber Technique

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Published on: May 26, 2021

Claudin Proteins And Neuronal Function.

Jérôme Devaux¹, Bozena Fykkolodziej², Alexander Gow³

¹Département Signalisation Neuronale, CRN2M, UMR 6231, CNRS, Université de la Méditerranée-Université Paul Cézanne, IFR Jean Roche, Marseille, France.

Current Topics in Membranes

|July 12, 2014

Summary

This summary is machine-generated.

Claudins, key proteins in tight junctions (TJs), are crucial for nervous system function. Research explores their role in glial cells, neuronal function, and myelin sheath integrity, impacting diseases like schizophrenia and multiple sclerosis.

Keywords:

axoglial experimental allergic encephalomyelitis oligodendrocyte specific protein proteolipid protein radial component saltatory conduction transverse bands

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Last Updated: Apr 27, 2026

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Study of the Functions and Activities of Neuronal K-Cl Co-Transporter KCC2 Using Western Blotting

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Published on: December 9, 2022

Area of Science:

Neuroscience
Cell Biology
Molecular Biology

Background:

The discovery of claudin proteins revolutionized the study of tight junctions (TJs).
TJs are implicated in various diseases, including neurological disorders.
Claudins are integral membrane proteins forming TJs, essential for cell-cell adhesion and barrier function.

Purpose of the Study:

To review the role of claudins in the nervous system.
To explore the involvement of TJs in glial cells and neuronal function.
To evaluate the function of TJs in the central nervous system (CNS) myelin sheath.

Main Methods:

Review of existing literature on claudins and TJs in the nervous system.
Analysis of electrophysiological evidence regarding TJ function in the CNS.
Evaluation of hypotheses concerning TJ roles in myelin and disease.

Main Results:

Electrophysiological data suggest claudins function in the CNS similarly to polarized epithelia.
Hypotheses propose TJs act as gatekeepers of immune-privileged myelin and provide adhesion within the myelin sheath.
CNS myelin TJs are linked to behavioral disorders and demyelinating diseases.

Conclusions:

Claudins play a significant role in CNS function, particularly in glial cells and myelin.
Understanding CNS TJs offers insights into neurological and psychiatric disorders.
Further research into claudins and TJs is vital for understanding and treating CNS diseases.