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Updated: Apr 27, 2026
Use of Ultra-high Field MRI in Small Rodent Models of Polycystic Kidney Disease for In Vivo Phenotyping and Drug Monitoring
Published on: June 23, 2015
Murine Models of Polycystic Kidney Disease
Luis Fernando Menezes1, Gregory George Germino1
1Kidney Disease Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Building 10 Room 8D46, 10 Center Drive, Bethesda, MD 20892.
Abstract:
Polycystic diseases affect approximately 1/1000 and are important causes of kidney failure. No therapies presently are in clinical practice that can prevent disease progression. Multiple mouse models have been produced for the genetic forms of the disease that most commonly affect humans. In this report, we review recent progress in the field and describe some of the outstanding challenges.
Insights
Polycystic kidney disease affects 1 in 1000 people and is a leading cause of kidney failure. Current treatments cannot halt disease progression, but new research shows promise in mouse models.
Area of Science:
- Nephrology
- Genetics
- Translational Medicine
Background:
- Polycystic kidney diseases (PKDs) affect approximately 1 in 1000 individuals.
- These conditions are a significant cause of end-stage renal disease.
- Currently, no therapies exist to prevent PKD progression.
Purpose of the Study:
- To review recent advancements in polycystic kidney disease research.
- To highlight current challenges in developing effective therapies.
- To discuss the utility of mouse models in studying genetic forms of PKD.
Main Methods:
- Literature review of recent scientific publications on polycystic kidney diseases.
- Analysis of established and emerging mouse models for genetic PKDs.
- Synthesis of current therapeutic strategies and their limitations.
Main Results:
- Multiple mouse models accurately recapitulate human genetic PKD forms.
- Significant progress has been made in understanding disease mechanisms.
- Several potential therapeutic targets are under investigation.
Conclusions:
- Mouse models are crucial for advancing PKD research and drug development.
- Overcoming current challenges is essential for clinical translation.
- Future research directions aim to prevent disease progression and improve patient outcomes.
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