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Updated: Apr 27, 2026

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Optical diagnostic techniques for use in lesions of the head and neck: review of the latest developments
Ben Green1, Alistair R M Cobb2, Peter A Brennan3
1Craniofacial Unit, Great Ormond Street Hospital for Children, London, UK; King's College London School of Medicine, Guy's Campus, London, UK.
Abstract:
Optical biopsy systems are a potential adjunct to the histopathological assessment of tissue specimens; they are not invasive and can give an immediate result. We review the most common optical biopsy techniques used to detect lesions of the head and neck: elastic scattering spectroscopy, microendoscopy, narrow band imaging, fluorescence, and optical coherence tomography, and discuss their clinical use.
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