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Skin Cancer

Skin Cancer

Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...

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Updated: Apr 27, 2026

Skin Biopsy for Diagnosing Discoid Lupus Erythematosus

Skin Biopsy for Diagnosing Discoid Lupus Erythematosus

Published on: June 10, 2025

Processing dermatological biopsies.

Gene Kim¹, Brittney DeClerck, Eric Sorenson

¹Department of Pathology, USC Keck School of Medicine, 1500 San Pablo St, NIT Rm 214, Los Angeles, CA, 90033, USA, gene.kim@med.usc.edu.

Methods in Molecular Biology (Clifton, N.J.)

|July 13, 2014

Summary

This summary is machine-generated.

Handling dermatological biopsies presents unique challenges due to specimen size and shape variations. Specialized techniques are crucial for accurate processing and diagnosis of skin, alopecia, and nail biopsies.

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Last Updated: Apr 27, 2026

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CUBIC Protocol Visualizes Protein Expression at Single Cell Resolution in Whole Mount Skin Preparations

CUBIC Protocol Visualizes Protein Expression at Single Cell Resolution in Whole Mount Skin Preparations

Published on: August 4, 2016

Area of Science:

Dermatopathology
Surgical Pathology
Histotechnology

Background:

Dermatological biopsies serve diverse diagnostic roles across various anatomical sites.
Specimen variability in size, shape, and anatomical origin complicates standard processing protocols.

Purpose of the Study:

To outline specialized techniques for processing challenging dermatological specimens.
To address the unique requirements for evaluating biopsies related to alopecia, nail disorders, and direct immunofluorescence.

Main Methods:

Discusses techniques for optimizing sample handling of small and variably shaped skin biopsies.
Details specific considerations for processing nail clippings and scalp biopsies for alopecia.
Explains protocols for frozen sections and specimens for direct immunofluorescence.

Main Results:

Effective processing ensures sufficient tissue sampling and proper specimen orientation.
Specialized methods improve diagnostic accuracy for a range of dermatological conditions.
Standardized approaches enhance the reliability of results for immunofluorescence studies.

Conclusions:

Tailored processing techniques are essential for accurate dermatopathological diagnosis.
Addressing specimen-specific challenges improves the utility of biopsies for clinical decision-making.
This chapter provides a practical guide for histotechnologists and pathologists handling dermatological specimens.