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RNAscope for In situ Detection of Transcriptionally Active Human Papillomavirus in Head and Neck Squamous Cell Carcinoma
Published on: March 11, 2014
Human papillomavirus testing in head and neck squamous cell carcinoma: best practice for diagnosis
Andrew Schache1, James Croud, Max Robinson
1Department of Molecular and Clinical Cancer Medicine, University of Liverpool, Pembroke Place, Liverpool, Merseyside, L3 5PS, UK.
Abstract:
Human papillomavirus (HPV)-associated oropharyngeal carcinoma is now recognized as a clinically distinct subtype of head and neck cancer with important prognostic implications. HPV testing is recommended as the standard of care for all patients diagnosed with oropharyngeal squamous cell carcinoma. Here, we describe a practical approach to HPV testing within the setting of the diagnostic histopathology laboratory.
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