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Updated: Apr 27, 2026

Synthesis of Near-Infrared Emitting Gold Nanoclusters for Biological Applications
Published on: March 22, 2020
Exploring luminescence-based temperature sensing using protein-passivated gold nanoclusters
Xi Chen1, Jeremy B Essner, Gary A Baker
1Department of Chemistry, University of Missouri-Columbia, Columbia, MO 65211, USA. bakergar@missouri.edu.
Abstract:
We explore the analytical performance and limitations of optically monitoring aqueous-phase temperature using protein-protected gold nanoclusters (AuNCs). Although not reported elsewhere, we find that these bio-passivated AuNCs show pronounced hysteresis upon thermal cycling. This unwanted behaviour can be eliminated by several strategies, including sol-gel coating and thermal denaturation of the biomolecular template, introducing protein-templated AuNC probes as viable nanothermometers.
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