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Periocular corticosteroid injections in uveitis: effects and complications
H Nida Sen1, Susan Vitale1, Sapna S Gangaputra2
1Laboratory of Immunology, National Eye Institute, Bethesda, Maryland.
Ophthalmology
|July 15, 2014
Summary
Periocular corticosteroid injections effectively controlled ocular inflammation and improved vision in most patients with uveitis. However, a significant number experienced complications like cataracts and ocular hypertension.
Area of Science:
- Ophthalmology
- Immunology
Background:
- Ocular inflammatory disorders, such as uveitis, can lead to significant vision loss.
- Corticosteroids are commonly used to manage intraocular inflammation.
- Periocular injections offer a localized delivery method for corticosteroids.
Purpose of the Study:
- To evaluate the efficacy and safety of periocular depot corticosteroid injections.
- To assess outcomes in patients with various ocular inflammatory conditions.
Main Methods:
- Multicenter, retrospective cohort study involving 914 patients (1192 eyes).
- Data collected from the Systemic Immunosuppressive Therapy for Eye Diseases Cohort Study.
- Key outcomes included inflammation control, visual acuity (VA) improvement, and complications like cataract and ocular hypertension.
Main Results:
- 72.7% of eyes achieved inflammation control within 6 months.
- 49.7% of eyes improved visual acuity to ≥ 20/40 within 6 months.
- Complications included ocular hypertension (34.0% by 12 months) and cataract development (20.2% within 12 months in phakic eyes).
Conclusions:
- Periocular corticosteroid injections are effective for treating intraocular inflammation and improving vision, particularly in cases of macular edema.
- While beneficial for a majority, these injections are associated with a notable incidence of cataracts and elevated intraocular pressure.
- Treatment outcomes were consistent across different anatomical locations of uveitis.
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