Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Inflammatory Bowel Disease III: Crohn's Disease01:25

Inflammatory Bowel Disease III: Crohn's Disease

29
Crohn’s disease is a chronic, relapsing form of inflammatory bowel disease characterized by segmental, transmural inflammation that can affect any part of the gastrointestinal tract. Its pathogenesis arises from a combination of genetic susceptibility, environmental exposures, epithelial barrier dysfunction, and immune dysregulation. Together, these factors lead to an exaggerated immune response against components of the gut microbiome.Genetic and Environmental InfluencesMultiple genetic...
29
Chronic Bowel Disorders: Introduction01:17

Chronic Bowel Disorders: Introduction

896
Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
896
Inflammatory Bowel Disease II: Crohn's Disease01:30

Inflammatory Bowel Disease II: Crohn's Disease

1.6K
Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
1.6K
Skin Diseases and Disorders01:23

Skin Diseases and Disorders

5.1K
Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
5.1K
Autoimmune Disorders01:29

Autoimmune Disorders

2.3K
Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune...
2.3K
Inflammatory Bowel Disease I: Introduction01:26

Inflammatory Bowel Disease I: Introduction

34
Inflammatory bowel disease is a group of chronic disorders marked by recurrent inflammation of the gastrointestinal tract due to an abnormal immune response against gut microflora. This leads to tissue damage. The two main forms are Crohn’s disease and ulcerative colitis.Crohn’s DiseaseCrohn’s disease is a relapsing inflammatory disorder that can affect any part of the GI tract, from the mouth to the anus. It involves all layers of the bowel wall (transmural) and shows...
34

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Honeycomb-pattern of plantar keratoderma in a patient with biallelic CTSC pathogenic variants.

Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·2026
Same author

What's New in JEACP-Editor-in-Chief's Insights: Highlights from the latest issue.

Journal of the European Academy of Dermatology and Venereology : JEADV·2026
Same author

Infantile Transient Smooth Muscle Contraction of the Skin in Two Sisters.

Pediatric dermatology·2026
Same author

The worldwide burden of skin diseases: Lessons from the Global Burden of Disease data.

Journal of the European Academy of Dermatology and Venereology : JEADV·2026
Same author

Atypical Neurofibromatous Neoplasms of Uncertain Biological Potential in Children with Neurofibromatosis Type 1: Report of Two Patients and Review.

International journal of surgical pathology·2026
Same author

Erdafitinib-Induced Flexural Calcinosis Cutis in a Pediatric Patient: A Drug-Specific Side-Effect?

Pediatric dermatology·2026

Related Experiment Video

Updated: Apr 27, 2026

Skin Biopsy for Diagnosing Discoid Lupus Erythematosus
05:44

Skin Biopsy for Diagnosing Discoid Lupus Erythematosus

Published on: June 10, 2025

1.7K

Autoinflammatory syndromes for the dermatologist.

Paula Dávila-Seijo1, Angela Hernández-Martín1, Antonio Torrelo1

  • 1Department of Dermatology, Hospital del Niño Jesús, Menéndez Pelayo 65, 28009 Madrid, Spain.

Clinics in Dermatology
|July 15, 2014
PubMed
Summary

Autoinflammatory diseases involve inappropriate immune activation, causing recurrent fevers and inflammation. Recognizing skin manifestations in children is crucial for early diagnosis and treatment of these immune-mediated conditions.

More Related Videos

Granulocyte-dependent Autoantibody-induced Skin Blistering
12:23

Granulocyte-dependent Autoantibody-induced Skin Blistering

Published on: October 12, 2012

9.9K
Dermoscopy Aids in the Diagnosis of Discoid Lupus Erythematosus
05:39

Dermoscopy Aids in the Diagnosis of Discoid Lupus Erythematosus

Published on: May 16, 2025

931

Related Experiment Videos

Last Updated: Apr 27, 2026

Skin Biopsy for Diagnosing Discoid Lupus Erythematosus
05:44

Skin Biopsy for Diagnosing Discoid Lupus Erythematosus

Published on: June 10, 2025

1.7K
Granulocyte-dependent Autoantibody-induced Skin Blistering
12:23

Granulocyte-dependent Autoantibody-induced Skin Blistering

Published on: October 12, 2012

9.9K
Dermoscopy Aids in the Diagnosis of Discoid Lupus Erythematosus
05:39

Dermoscopy Aids in the Diagnosis of Discoid Lupus Erythematosus

Published on: May 16, 2025

931

Area of Science:

  • Immunology
  • Pediatrics
  • Dermatology

Background:

  • Autoimmunity is well-understood, but other immune-mediated diseases are emerging.
  • Autoinflammatory diseases involve antigen-independent immune activation, causing recurrent fevers and systemic inflammation.
  • Cutaneous manifestations are common in autoinflammatory diseases and can be key diagnostic clues.

Purpose of the Study:

  • To review the skin manifestations of autoinflammatory diseases in children.
  • To highlight the importance of recognizing dermatologic signs for early diagnosis and treatment.

Main Methods:

  • Literature review focusing on autoinflammatory diseases and their skin presentations in pediatric populations.

Main Results:

  • Autoinflammatory diseases present with recurrent fevers and multisystemic inflammation.
  • Skin manifestations are varied and often serve as early indicators of these syndromes.
  • Early recognition of cutaneous features aids in prompt diagnosis and management.

Conclusions:

  • Cutaneous features are vital for identifying autoinflammatory diseases in children.
  • Timely diagnosis and treatment are essential for improving patient outcomes and survival.