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Updated: Apr 27, 2026

A Patient-Derived Xenograft Model for Venous Malformation
Published on: June 15, 2020
Radiotherapy for intraarticular venous malformations of the knee
Takeshi Fujita1, Tomoaki Okimoto2, Katsuyoshi Ito3
1Department of Radiology, Ube Industries, Ltd., Central Hospital, Ube, Yamaguchi, Japan.
Abstract:
Intraarticular venous malformation (IAVM) of the knee is a rare vascular disease that manifests with pain, swelling, and hemarthrosis. A young man with left knee pain and swelling was admitted to our institution for the treatment of the IAVM of the left knee which was diagnosed by a local orthopedic doctor via arthroscopy. A total dose of 40 Gy of radiotherapy was delivered with a daily dose of 2.0 Gy using 6 MV X-ray beams and a linear accelerator through anteroposterior portals. Fifteen months after radiotherapy, follow-up examination using radiologic imaging showed distinct shrinkage of the venous malformations. Swelling and pain of the left knee had decreased, and range of motion of the left knee was maintained. This report describes a case involving a 38-year-old man with IAVM of the left knee in whom favorable outcomes were obtained in response to radiotherapy.
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