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The association between apolipoprotein A-I and prostacyclin binding in human serum
W F O'Brien1, C Torres, R Benoit
1Dept. of Obstetrics and Gynecology, University of South Florida College of Medicine, Tampa 33612.
Abstract:
The stability of Prostacyclin in human blood is dependent upon binding to circulating proteins. Although this binding has been considered to be primarily due to albumin, a recent report has suggested that apolipoprotein A-I is responsible. We compared prostacyclin binding to the concentration of albumin and apolipoprotein A-I in several groups of sera with known differences in the ability to bind prostacyclin. Our results indicate a strong correlation with albumin concentration but no correlation between binding and the concentration of apolipoprotein A-I. It appears that in the human circulation albumin concentration is the most important determinant of prostacyclin binding.