Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Insulin Secretory Vesicles01:05

Insulin Secretory Vesicles

6.2K
Insulin secretory vesicles release insulin to stimulate blood glucose uptake and regulate carbohydrate metabolism. When the blood glucose levels increase, glucose enters the pancreatic β-islet cells through glucose transporters. Once inside, glucose is metabolized through glycolysis, the citric acid cycle, and the electron transport chain, producing ATP. This increase in ATP concentration closes ATP-sensitive potassium channels, leading to depolarization of the membrane and the opening of...
6.2K
SDS-PAGE01:27

SDS-PAGE

22.9K
Gel electrophoresis is a method that separates biological macromolecules like nucleic acids or proteins by forcing them to pass through a gel matrix under an electric field.
A variation of gel electrophoresis, termed  polyacrylamide gel electrophoresis (PAGE), is commonly used for separating proteins according to their molecular size by passing them through a polyacrylamide gel. Because of the varying charges associated with amino acid side chains, PAGE can be used to separate intact...
22.9K
Seedless Vascular Plants03:24

Seedless Vascular Plants

54.5K
Seedless Vascular Plants Were the First Tall Plants on Earth
54.5K
Introduction to Seed Plants03:40

Introduction to Seed Plants

53.9K
Most plants are seed plants—characterized by seeds, pollen, and reduced gametophytes. Seed plants include gymnosperms and angiosperms.
53.9K
Accessory Structures of the Skin: Sebaceous Glands01:21

Accessory Structures of the Skin: Sebaceous Glands

5.4K
A sebaceous gland is a type of oil gland found almost all over the skin ( except palms and soles) and helps lubricate and waterproof the skin and hair. Most sebaceous glands are associated with hair follicles. They generate and excrete sebum, a mixture of lipids, onto the skin surface, thereby naturally lubricating the dry and dead layer of keratinized cells of the stratum corneum, keeping it pliable.
These glands that produce the oils on the skin and hair are holocrine glands. The mature...
5.4K
Seed Structure and Early Development of the Sporophyte02:33

Seed Structure and Early Development of the Sporophyte

27.7K
Seed structures are composed of a protective seed coat surrounding a plant embryo, and a food store for the developing embryo. The embryo contains the precursor tissues for leaves, stem, and roots. The endosperm and cotyledons—seed leaves—act as the food reserves for the growing embryo.
27.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The Combined Therapeutic Effect of Lenvatinib and ADI-PEG 20 in Advanced Hepatocellular Carcinoma: A Case Report.

In vivo (Athens, Greece)·2026
Same author

<i>GALNT14</i>-rs9679162 Genotypes Predict Post-immunotherapy Side Effect and Survival in Patients with Hepatitis B Virus-related Hepatocellular Carcinoma.

Journal of Cancer·2026
Same author

Targeting ST3GAL1 to downregulate ligands for the glycoimmune checkpoint Siglec-7 and reverse immune escape in hepatocellular carcinoma.

Cancer immunology, immunotherapy : CII·2026
Same author

A Deep Learning Prognostic Model for Diabetes Patients Using Bilateral Fundus Imaging.

Journal of diabetes science and technology·2026
Same author

Novel function of GTPBP2 in promoting hepatocellular carcinoma progression through inhibition of BTRC-mediated KRAS degradation.

Cancer cell international·2026
Same author

Exploratory analysis of lamivudine legacy and clonal selection of HBs truncation mutants in HBV-related hepatocellular carcinoma.

Infectious agents and cancer·2025
Same journal

Associating liver partition and portal vein ligation for staged hepatectomy (ALPPS) <i>vs.</i> liver transplantation for borderline-resectable colorectal liver metastases: evidence not yet definitive.

Hepatobiliary surgery and nutrition·2026
Same journal

Immune-mediated tumor regression and subsequent escape driven by antigen loss and major histocompatibility complex (MHC) class I downregulation following GPC3 DNA vaccination in hepatocellular carcinoma.

Hepatobiliary surgery and nutrition·2026
Same journal

The evolution of liver graft preservation strategies in liver transplantation.

Hepatobiliary surgery and nutrition·2026
Same journal

Adjuvant therapy after R0 resection for primary hepatic sarcomatoid carcinoma.

Hepatobiliary surgery and nutrition·2026
Same journal

Chinese expert consensus on conversion and perioperative therapy of primary liver cancer (2024 edition).

Hepatobiliary surgery and nutrition·2026
Same journal

Revisiting treatment paradigms for colorectal liver metastases: liver transplant or associating liver partition and portal vein ligation for staged hepatectomy?

Hepatobiliary surgery and nutrition·2026
See all related articles

Related Experiment Video

Updated: Apr 27, 2026

Transverse Sectioning of Mature Rice Oryza sativa L. Kernels for Scanning Electron Microscopy Imaging Using Pipette Tips as Immobilization Support
05:22

Transverse Sectioning of Mature Rice Oryza sativa L. Kernels for Scanning Electron Microscopy Imaging Using Pipette Tips as Immobilization Support

Published on: January 25, 2022

3.6K

OPN sesame.

Kung-Hao Liang1, Chau-Ting Yeh1

  • 11 Liver Research Center, Chang Gung Memorial Hospital, Taipei, Taiwan ; 2 Molecular Medicine Research Center, Chang Gung University, Taoyuan, Taiwan.

Hepatobiliary Surgery and Nutrition
|July 15, 2014
PubMed
Summary
This summary is machine-generated.

Osteopontin (OPN) drives hepatocellular carcinoma (HCC) growth and attracts macrophages. High OPN and peritumoral macrophage (PTM) levels correlate with poor HCC prognosis, suggesting new therapeutic targets.

Keywords:
Metastasiscancer recurrenceearly detectioninflammation

More Related Videos

Preparation of Intact Tissue for Microscopic Analysis of the Endosperm Cell Layer in Developing and Mature Arabidopsis Seeds
06:28

Preparation of Intact Tissue for Microscopic Analysis of the Endosperm Cell Layer in Developing and Mature Arabidopsis Seeds

Published on: May 16, 2025

1.3K
A Simple Dry Sectioning Method for Obtaining Whole-Seed-Sized Resin Section and Its Applications
10:10

A Simple Dry Sectioning Method for Obtaining Whole-Seed-Sized Resin Section and Its Applications

Published on: January 23, 2021

4.1K

Related Experiment Videos

Last Updated: Apr 27, 2026

Transverse Sectioning of Mature Rice Oryza sativa L. Kernels for Scanning Electron Microscopy Imaging Using Pipette Tips as Immobilization Support
05:22

Transverse Sectioning of Mature Rice Oryza sativa L. Kernels for Scanning Electron Microscopy Imaging Using Pipette Tips as Immobilization Support

Published on: January 25, 2022

3.6K
Preparation of Intact Tissue for Microscopic Analysis of the Endosperm Cell Layer in Developing and Mature Arabidopsis Seeds
06:28

Preparation of Intact Tissue for Microscopic Analysis of the Endosperm Cell Layer in Developing and Mature Arabidopsis Seeds

Published on: May 16, 2025

1.3K
A Simple Dry Sectioning Method for Obtaining Whole-Seed-Sized Resin Section and Its Applications
10:10

A Simple Dry Sectioning Method for Obtaining Whole-Seed-Sized Resin Section and Its Applications

Published on: January 23, 2021

4.1K

Area of Science:

  • Oncology
  • Immunology
  • Biochemistry

Background:

  • Osteopontin (OPN) is implicated in cancer progression and immune cell recruitment.
  • Hepatocellular carcinoma (HCC) is a significant global health concern.
  • The tumor microenvironment, particularly macrophage infiltration, influences cancer outcomes.

Purpose of the Study:

  • To investigate the clinical significance of Osteopontin (OPN) expression in hepatocellular carcinoma (HCC).
  • To examine the association between tumoral OPN and peritumoral macrophage (PTM) infiltration.
  • To explore the potential of the OPN-macrophage interaction as a therapeutic target for HCC.

Main Methods:

  • Analysis of tumoral Osteopontin (OPN) expression levels.
  • Assessment of peritumoral macrophage (PTM) infiltration in HCC tissues.
  • Correlation analysis between OPN expression, PTM infiltration, and patient prognosis.

Main Results:

  • Concurrent detection of tumoral OPN expression and peritumoral macrophage (PTM) infiltration was significantly associated with poor postoperative prognosis in HCC patients.
  • Osteopontin (OPN) acts as a chemoattractant for macrophages, influencing the tumor microenvironment.
  • These findings highlight a critical interplay between OPN and macrophages in HCC progression.

Conclusions:

  • Tumoral Osteopontin (OPN) expression and peritumoral macrophage (PTM) infiltration are key indicators of poor prognosis in hepatocellular carcinoma (HCC).
  • Targeting the interaction between OPN and macrophages presents a promising strategy for novel anticancer treatments in HCC.
  • Further research into the OPN-macrophage axis could lead to improved therapeutic interventions for HCC.