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Updated: Apr 27, 2026
Evaluation of Biomarkers in Glioma by Immunohistochemistry on Paraffin-Embedded 3D Glioma Neurosphere Cultures
Published on: January 9, 2019
Evaluation of eight plasma proteins as candidate blood-based biomarkers for malignant gliomas
Ryan P Lange1, Allen Everett, Pratima Dulloor
1The Johns Hopkins University, School of Medicine, Departments of1 Pediatrics2 Emergency Medicine3 Neurosurgery,4 and Oncology,5 Baltimore, MD, USA; The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins , Baltimore, MD , USA 6.
Abstract:
Eight brain-derived proteins were evaluated regarding their potential for further development as a blood-based biomarker for malignant gliomas. Plasma levels for glial fibrillary acidic protein, neurogranin, brain-derived neurotrophic factor, intracellular adhesion molecule 5, metallothionein-3, beta-synuclein, S100 and neuron specific enolase were tested in plasma of 23 patients with high-grade gliomas (WHO grade IV), 11 low-grade gliomas (WHO grade II), and 15 healthy subjects. Compared to the healthy controls, none of the proteins appeared to be specific for glioblastomas. However, the data are suggestive of higher protein levels in gliosarcomas (n = 2), which may deserve further exploration.
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