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Updated: Aug 6, 2026
A Protocol for Explant Cultures of IDH1-mutant Diffuse Low-grade Gliomas
Published on: May 9, 2025
ALT phenotype assessment in IDH-mutant astrocytoma supports biologic consequence of ATRX missense mutations
Oguzhan O Kizilkaya1, Kevin Y Zhang1, Mohamed Sherief2
1Department of Pathology, Johns Hopkins University, Baltimore, Maryland, USA.
Abstract:
A meaningful subset of IDH-mutant astrocytoma harbors ATRX missense variants that retain ATRX IHC immunoreactivity yet exhibit functional ALT activation, supporting the biologic relevance of these missense mutations.
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