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Updated: Apr 27, 2026

A Methodological Approach to Non-invasive Assessments of Vascular Function and Morphology
Published on: February 7, 2015
Close relationship between serum hyaluronan levels and vascular function in patients with type 2 diabetes
Miwa Morita1, Shozo Yano, Yutaka Ishibashi
1Department of Internal Medicine 1 .
Objective:
To clarify the relationship between serum hyaluronan levels and vascular function in type 2 diabetic patients.
Methods:
A cross-sectional cohort study.
Results:
In multivariate regression analysis, endothelium-dependent flow-mediated dilation was associated with age and duration of diabetes, but not with serum hyaluronan level, while endothelium-independent nitroglycerine-mediated dilation (NMD) was only associated with serum hyaluronan level (standardized estimate = -0.401, p = 0.003). NMD in the lowest tertile of hyaluronan level was significantly higher than the other tertiles (15.9% versus 12.5% and 10.4%, p = 0.047 and p = 0.002, respectively).
Conclusions:
Serum hyaluronan level may be useful as a surrogate marker for early changes in the vascular function, which often occurs in patients with diabetes mellitus.
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