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The diagnostic efficacy of nectin 4 expression in ovarian cancer patients
Enas Samir Nabih1, Fayda Ibrahim Abdel Motaleb, Fekria Ahmed Salama
1Department of Medical Biochemistry and.
Context:
Nectin 4 plays a significant role in cancer cell growth and invasion.
Objective:
To explore its diagnostic role in ovarian cancer.
Materials And Methods:
Evaluation of nectin 4 expression in ovarian biopsies by real-time PCR and serum nectin 4 and CA-125 by ELISA in 39 ovarian cancer patients, 21 females with benign ovarian neoplasms and 25 control females.
Results:
Nectin 4 expression was significantly higher in ovarian cancer patients and it was significantly correlated to serum nectin 4 and CA-125.
Conclusions:
Ovarian tissue expression and serum nectin 4 appear to be potential markers in ovarian cancer.
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