Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Pharmaceutical Poisoning: Potential Scenarios01:26

Pharmaceutical Poisoning: Potential Scenarios

116
Pharmaceutical poisoning can occur through various channels, impacting an estimated 2 million hospitalized patients in the U.S. annually with serious adverse drug responses. These scenarios encompass both therapeutic uses, such as drug toxicity, where even standard dosages can lead to severe central nervous system depression, and non-therapeutic exposures, including accidental ingestion by children, and environmental and occupational exposures.Unintentional poisonings often involve exploratory...
116
Pharmacokinetics in Pediatric Patients: Drug Excretion01:26

Pharmacokinetics in Pediatric Patients: Drug Excretion

400
In pediatric medicine, understanding the renal function and drug elimination nuances is crucial for administering safe and effective treatments. Newborns, in particular, display markedly slower renal functions than adults, profoundly affecting how drugs are cleared from their bodies. This slower drug clearance requires clinicians to extend the dosing intervals for many medications to prevent drug accumulation and toxicity while ensuring therapeutic efficacy.One key area where these adjustments...
400
Pharmacokinetics in Pediatric Patients: Drug Metabolism01:24

Pharmacokinetics in Pediatric Patients: Drug Metabolism

405
In pediatric care, understanding the nuances of hepatic drug metabolism is crucial, as it significantly differs from that of adults. This divergence is primarily due to the developmental stage of drug-metabolizing enzymes, which affects how medications are processed in the body. In neonates, for instance, the activity of Phase I enzymes—critical for the initial breakdown of drugs—is markedly reduced, functioning at just 20–40% of the levels seen in adults. This reduction poses...
405
Drug Dosing: Infants and Children01:29

Drug Dosing: Infants and Children

1.0K
Pediatric patient dosages diverge from adults due to disparities in body surface area, total body water, and extracellular fluid per kilogram of body weight. The dosing regimen considers the variations in pharmacokinetics and pharmacology across distinct age groups, encompassing preterm newborns, infants, young children, older children, and adolescents. Calculation of pediatric patient doses is predicated on determining body surface area, which exhibits a superior correlation with the child's...
1.0K
Pharmacokinetics in Pediatric Patients: Drug Distribution01:17

Pharmacokinetics in Pediatric Patients: Drug Distribution

547
Drug distribution in the pediatric population exhibits unique challenges and considerations due to the physiological differences between children, particularly neonates and infants, and adults. A crucial aspect of pediatric pharmacology is understanding how these differences impact the pharmacokinetics of various drugs, necessitating age-specific dosing strategies to ensure efficacy and safety.Neonates and infants have a higher total body water content, ~75%–90% of their body weight,...
547
Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption01:23

Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption

954
Understanding the physiological differences in the pediatric population is crucial for effective pharmacotherapy. Neonates, infants, and children exhibit significant variations in gastric pH, gastric emptying time, intestinal transit time, and biliary function. These variations profoundly affect oral drug absorption, necessitating a nuanced approach to pediatric dosing.Neonates present with a unique physiological profile, having a gastric pH greater than 4 and faster and more irregular gastric...
954

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The Daily Grind.

The New England journal of medicine·2026
Same author

Improving Adherence to Pediatric Hypertension Guidelines: Go the Distance.

Pediatrics·2026
Same author

Death after Total Hip Arthroplasty in Patients with Compensated Heart Failure: Retrospective Cohort Study.

Hawai'i journal of health & social welfare·2026
Same author

Influenza Vaccination Trends Among Children and Adolescents, 2017-2023.

JAMA network open·2026
Same author

Health-Related School Absenteeism Among US School-Age Children With Chronic Health and Social Needs.

JAMA pediatrics·2026
Same author

Loeys-Dietz syndrome: 2026 updated care management primer.

Genetics in medicine : official journal of the American College of Medical Genetics·2026
Same journal

Severe Postoperative Hypernatremia in an Adolescent Following Sleeve Gastrectomy.

Pediatrics·2026
Same journal

Barriers to Implementing SMART for Asthma in Pediatric Primary Care.

Pediatrics·2026
Same journal

Blood Lead Testing Among Children Enrolled in Medicaid.

Pediatrics·2026
Same journal

From Screening to Support: Crafting Social Needs Response Systems That Work for Families.

Pediatrics·2026
Same journal

A Social Care Intervention in Pediatric Practices: A Stepped Wedge Cluster Trial.

Pediatrics·2026
Same journal

Pediatric Cheerleading-Related Head Injuries and the "Double Down" Rule Change.

Pediatrics·2026
See all related articles

Related Experiment Video

Updated: Apr 27, 2026

A Novel Approach for the Administration of Medications and Fluids in Emergency Scenarios and Settings
06:59

A Novel Approach for the Administration of Medications and Fluids in Emergency Scenarios and Settings

Published on: November 9, 2016

33.8K

Interventions to reduce pediatric medication errors: a systematic review.

Michael L Rinke1, David G Bundy2, Christina A Velasquez3

  • 1Department of Pediatrics, Children's Hospital at Montefiore, Bronx, New York; mrinke@montefiore.org.

Pediatrics
|July 16, 2014
PubMed
Summary
This summary is machine-generated.

Pediatric medication errors can be reduced with interventions like computerized provider order entry and preprinted order sheets. Further research is needed to identify optimal strategies and address knowledge gaps in error reduction.

Keywords:
computerized physician order entryinterventionmedication errorpediatricsystematic review

More Related Videos

Guidelines for Elective Pediatric Fiberoptic Intubation
11:19

Guidelines for Elective Pediatric Fiberoptic Intubation

Published on: January 17, 2011

17.5K

Related Experiment Videos

Last Updated: Apr 27, 2026

A Novel Approach for the Administration of Medications and Fluids in Emergency Scenarios and Settings
06:59

A Novel Approach for the Administration of Medications and Fluids in Emergency Scenarios and Settings

Published on: November 9, 2016

33.8K
Guidelines for Elective Pediatric Fiberoptic Intubation
11:19

Guidelines for Elective Pediatric Fiberoptic Intubation

Published on: January 17, 2011

17.5K

Area of Science:

  • Pediatric patient safety
  • Health informatics
  • Clinical pharmacology

Background:

  • Medication errors in children lead to significant morbidity and mortality.
  • Existing literature on interventions to reduce pediatric medication errors has gaps.
  • A comprehensive review and meta-analysis were needed to assess intervention effectiveness.

Purpose of the Study:

  • To evaluate the effectiveness of interventions aimed at reducing medication errors in children.
  • To identify gaps in the current research landscape.
  • To conduct meta-analyses on comparable studies to quantify intervention impact.

Main Methods:

  • Systematic literature searches were conducted across multiple databases (PubMed, Embase, Scopus, Web of Science, Cochrane Library, CINAHL).
  • Inclusion criteria focused on peer-reviewed original studies evaluating interventions for pediatric medication errors.
  • Two independent authors reviewed abstracts and full-text articles, with sequential data extraction.

Main Results:

  • Out of 274 full-text articles reviewed, 63 were included in the analysis.
  • Significant research gaps were identified, with limited studies in community hospitals, ambulatory settings, and on dispensing errors or cost-effectiveness.
  • Computerized provider order entry (CPOE) with clinical decision support showed a 36%-87% reduction in prescribing errors; preprinted order sheets showed a 27%-82% reduction.

Conclusions:

  • Interventions can effectively reduce pediatric medication errors.
  • Optimal intervention strategies require further investigation.
  • Future research should prioritize understudied areas, standardize definitions and outcomes, and assess cost-effectiveness.