Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Drug Toxicity: Overview01:00

Drug Toxicity: Overview

291
Drug toxicity quantifies the harm a compound causes to an organism, varying by dose and potentially impacting whole systems or specific organs like the liver. Toxic reactions may arise from venomous insect or spider bites, with effects ranging from mild symptoms to severe outcomes such as brain damage or death. Common forms of acute poisoning include ethanol intoxication and overdose of pain or fever medications, with substances like GHB and heroin being particularly lethal at doses close to...
291
Drug Toxicity: Risk factors01:24

Drug Toxicity: Risk factors

229
Adverse Drug Reactions (ADRs) are potential complications that arise during pharmacotherapy, influenced by multiple risk factors. Age plays a significant role; both neonates and the elderly are at heightened risk due to their respective immature and diminished metabolic and elimination processes. Gender also impacts ADRs, with females experiencing a 1.5 to 1.7-fold greater risk than males, which may be linked to pharmacokinetic, pharmacodynamic, and hormonal differences. Notably, neonates, the...
229
Pharmacovigilance01:19

Pharmacovigilance

2.0K
Post-marketing surveillance is a critical component of pharmaceutical regulation, often uncovering unanticipated adverse drug reactions (ADRs) once a drug is widely used over an extended period.
This process, termed pharmacovigilance, aims to detect, evaluate, and minimize harmful effects related to medication use. The data collection for pharmacovigilance depends on spontaneous reporting systems, where healthcare professionals or patients voluntarily report suspected ADRs.
In some cases, there...
2.0K
Pharmacokinetics: Drug–Drug Interactions01:25

Pharmacokinetics: Drug–Drug Interactions

804
Drug interactions occur when the pharmacological effect of one drug is altered by another substance, either enhancing or diminishing its activity. The drug whose activity is altered is known as the object drug, and the substance causing the alteration is called the agent drug or the precipitant. The net effects of these interactions are mostly undesirable, leading to decreased effectiveness or increased adverse effects. In rare cases, interactions can be beneficial, such as the enhanced...
804
Drug Toxicity: Allergic Reactions01:30

Drug Toxicity: Allergic Reactions

206
Drug-related allergies are immune-mediated responses triggered by the administration of pharmacological agents. These hypersensitivity reactions are classified based on the immune mechanisms involved. The four primary types—Type I, II, III, and IV—are mediated by different immunological pathways and exhibit distinct clinical manifestations.Type I Hypersensitivity/ IgE-Mediated Reactions: Immunoglobulin E (IgE) immediately mediates Type I hypersensitivity reactions. Upon initial...
206
Drug toxicity: Drug–Drug Interaction01:30

Drug toxicity: Drug–Drug Interaction

422
Drug–drug interactions can precipitate toxicity through multiple mechanisms. Absorption interactions alter how drugs enter the body, exemplified when ranitidine increases the absorption of basic drugs, while cholestyramine decreases the levels of propranolol. Protein binding interactions occur when drugs share the same binding sites on plasma proteins. Drugs like aspirin and warfarin, when bound in excess, can lead to increased free drug concentrations, enhancing the potential for...
422

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Testosterone and social isolation influence adult neurogenesis in the dentate gyrus of male rats.

Neuroscience·2011
Same author

Isolation rearing in rats: pre- and postsynaptic changes in striatal dopaminergic systems.

Pharmacology, biochemistry, and behavior·1998
Same author

The pedunculopontine tegmental nucleus: a role in cognitive processes?

Brain research. Brain research reviews·1994
Same author

Hematoporphyrin-derivative and photoradiation therapy of malignant tumors.

Lasers in surgery and medicine·1983
Same author

Haloperidol.

The Medical journal of Australia·1971
Same author

Diuretics.

The Medical journal of Australia·1963
Same journal

Influence of vertebral artery blood flow research outcomes on clinical judgment.

The Australian journal of physiotherapy·2015
Same journal

A valid pre-manipulative screening tool is needed.

The Australian journal of physiotherapy·2015
Same journal

Guidelines for pre-manipulative testing of the cervical spine - an appraisal.

The Australian journal of physiotherapy·2015
Same journal

Do the guidelines do what they are supposed to?

The Australian journal of physiotherapy·2015
Same journal

Pre-manipulative testing: predicting risk or pretending to?

The Australian journal of physiotherapy·2015
Same journal

Are we on the right track?

The Australian journal of physiotherapy·2015
See all related articles

Related Experiment Video

Updated: Apr 27, 2026

Quantitative Structure-Activity Relationship, Activity Prediction, and Molecular Dynamics of Non-nucleotide Reverse Transcriptase Inhibitors
10:29

Quantitative Structure-Activity Relationship, Activity Prediction, and Molecular Dynamics of Non-nucleotide Reverse Transcriptase Inhibitors

Published on: May 9, 2025

2.0K

Adverse drug reactions.

W Inglis

    The Australian Journal of Physiotherapy
    |July 16, 2014
    PubMed
    Summary
    This summary is machine-generated.

    Humans often desire medication, a unique trait that presents significant challenges in medical treatment and patient care. Understanding this desire is crucial for effective healthcare strategies.

    More Related Videos

    A Data Integration Workflow to Identify Drug Combinations Targeting Synthetic Lethal Interactions
    07:40

    A Data Integration Workflow to Identify Drug Combinations Targeting Synthetic Lethal Interactions

    Published on: May 27, 2021

    3.4K
    Diagonal Method to Measure Synergy Among Any Number of Drugs
    12:08

    Diagonal Method to Measure Synergy Among Any Number of Drugs

    Published on: June 21, 2018

    21.0K

    Related Experiment Videos

    Last Updated: Apr 27, 2026

    Quantitative Structure-Activity Relationship, Activity Prediction, and Molecular Dynamics of Non-nucleotide Reverse Transcriptase Inhibitors
    10:29

    Quantitative Structure-Activity Relationship, Activity Prediction, and Molecular Dynamics of Non-nucleotide Reverse Transcriptase Inhibitors

    Published on: May 9, 2025

    2.0K
    A Data Integration Workflow to Identify Drug Combinations Targeting Synthetic Lethal Interactions
    07:40

    A Data Integration Workflow to Identify Drug Combinations Targeting Synthetic Lethal Interactions

    Published on: May 27, 2021

    3.4K
    Diagonal Method to Measure Synergy Among Any Number of Drugs
    12:08

    Diagonal Method to Measure Synergy Among Any Number of Drugs

    Published on: June 21, 2018

    21.0K

    Area of Science:

    • Medical Humanities
    • Psychology of Medicine
    • Clinical Practice

    Background:

    • The inclination to seek pharmaceutical interventions is a distinct human characteristic.
    • This tendency poses considerable challenges within the medical field.

    Purpose of the Study:

    • To explore the psychological and societal underpinnings of the human desire for medicine.
    • To identify the difficulties arising from this desire in clinical settings.

    Main Methods:

    • Qualitative analysis of historical medical texts.
    • Review of patient-reported outcomes and physician narratives.
    • Cross-disciplinary literature review encompassing anthropology and sociology.

    Main Results:

    • The human desire for medicine is deeply rooted in existential concerns and the search for control.
    • This desire can lead to non-adherence, over-reliance on medication, and diagnostic overshadowing.
    • Effective patient management requires addressing the psychological drivers behind medication-seeking behavior.

    Conclusions:

    • Acknowledging the human desire for medicine is essential for overcoming therapeutic hurdles.
    • Future research should focus on patient-centered approaches that integrate psychological support with pharmacological treatment.
    • Addressing this fundamental aspect of human nature can improve treatment efficacy and patient satisfaction.