A Practical Guide to Somatostatin Receptor Imaging with PET/Computed Tomography
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Updated: Oct 31, 2026

A Practical Guide for the Production and PET/CT Imaging of 68Ga-DOTATATE for Neuroendocrine Tumors in Daily Clinical Practice
Published on: April 17, 2019
Emma Boehm1, Ramin Alipour2, Javad Saghebi2
1Molecular Imaging and Therapeutic Nuclear Medicine, Cancer Imaging, Peter MacCallum Cancer Centre, Melbourne, VIC, Australia; Department of Clinical Pathology, Collaborative Centre for Cancer Genomic Medicine, University of Melbourne, Melbourne, VIC, Australia.
Abstract:
Somatostatin receptor (SSTR) imaging with PET/computed tomography (CT) is a key investigation for diagnosis, staging, restaging and evaluation of potential suitability for radionuclide therapy in patients with neuroendocrine tumors and other neoplasms. An understanding of the physiologic distribution of somatostatin receptors, patterns of nonmalignant SSTR expression as well as the technical factors that influence lesion intensity are essential for accurate reporting of SSTR PET/CT. Here we present a practical guide to SSTR PET/CT, highlighting important biological concepts and common pitfalls to assist with accurate reporting.
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