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Regulation of alternative splicing of CD44 in cancer

Lubomir Prochazka1, Radek Tesarik1, Jaroslav Turanek1

  • 1Department of Pharmacology and Immunotherapy, Veterinary Research Institute, Brno, Czech Republic.

Cellular Signalling
|July 16, 2014
PubMed

Insights

This review details regulators of CD44 alternative splicing in cancer. Understanding these mechanisms is key to explaining CD44 variant isoform switching and its role in cancer progression.

Area of Science:

  • Molecular Biology
  • Cancer Biology
  • Cell Biology

Background:

  • CD44 is a cell surface receptor involved in cell motility, survival, proliferation, and tumor microenvironment formation.
  • Alternative splicing of CD44 generates diverse isoforms with varying tissue-specific effects, often deregulated in cancer.
  • Understanding CD44 isoform variability is crucial for explaining its role in cancer progression.

Purpose of the Study:

  • To review and consolidate major regulators of CD44 alternative splicing in cancer.
  • To highlight experimentally proven effects on CD44 isoform switching.
  • To provide a foundation for understanding CD44 variant isoform occurrence in cancer.

Main Methods:

  • Literature review of documented regulators of CD44 alternative splicing.
  • Analysis of studies with experimentally validated effects on CD44 isoform switching.
  • Synthesis of information on CD44 splicing mechanisms and cancer-associated variants.

Main Results:

  • Identification of key regulators influencing CD44 alternative splicing in the context of cancer.
  • Compilation of evidence demonstrating the impact of these regulators on CD44 isoform switching.
  • Summary of the link between deregulated splicing and the generation of cancer-specific CD44 variants.

Conclusions:

  • Mechanisms of CD44 alternative splicing are critical for understanding cancer progression.
  • Further research into CD44 splicing regulators can elucidate the role of CD44 variant isoforms in cancer.
  • Targeting CD44 splicing may offer therapeutic strategies for cancer treatment.
Keywords:
Alternative splicingCD44CD44vCSCEMTIsoform switch

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