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Updated: Apr 27, 2026

Assessment and Evaluation of the High Risk Neonate: The NICU Network Neurobehavioral Scale
Published on: August 25, 2014
Identification and developmental assessment of children with neurological impairment
Insights
The developing brain is highly susceptible to injury during fetal development, birth, and early infancy. This critical period involves significant central nervous system growth and the emergence of complex motor functions.
Area of Science:
- Neuroscience
- Developmental Biology
- Pediatrics
Background:
- The brain undergoes critical development from fetal life through the first few months post-birth.
- This period is characterized by rapid central nervous system (CNS) maturation.
- The developing CNS integrates primitive reflexes into complex, adaptive motor behaviors.
Purpose of the Study:
- To highlight the vulnerability of the developing brain.
- To underscore the developmental processes occurring during this sensitive period.
- To emphasize the neurodevelopmental trajectory from primitive to integrated responses.
Main Methods:
- This study is a review of neurodevelopmental principles.
- It synthesizes information on fetal and early postnatal brain development.
- Focuses on the timing of CNS changes and behavioral emergence.
Main Results:
- The brain exhibits heightened vulnerability to damage during fetal development, birth, and early infancy.
- Rapid CNS development occurs during this period.
- A transition from primitive responses to complex, purposeful physical activities is observed.
Conclusions:
- The early postnatal period is a critical window for brain development and function.
- Understanding this vulnerability is crucial for preventing neurological damage.
- Interventions during this period can significantly impact long-term neurological outcomes.
Abstract:
During foetal life, at birth and in the first few post-natal months, the brain is particularly vulnerable to damage. It is at this time that there is rapid development of the central nervous system, a merging of early primitive responses with more complex and later, highly integrated and adaptive responses, and the development of purposeful physical activities.
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