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Message in a bottle: decoding medication injury patterns in the gastrointestinal tract
Journal of Clinical Pathology
|July 17, 2014
Summary
Medication injuries in the gastrointestinal tract (GIT) are common due to increased endoscopies and aging populations. This review highlights common and emerging drug-induced GIT injuries and their diagnostic patterns.
Area of Science:
- Gastroenterology
- Pathology
- Pharmacology
Background:
- Medication-related gastrointestinal tract (GIT) injuries are increasingly recognized.
- Factors contributing to this include more frequent endoscopic procedures, an aging demographic, and widespread polypharmacy.
Purpose of the Study:
- To review common and emerging medication-induced injuries within the gastrointestinal tract.
- To describe characteristic morphologic patterns of these injuries to aid diagnosis.
Main Methods:
- Literature review focusing on medication-induced gastrointestinal injuries.
- Categorization of injuries by organ system and morphologic patterns.
Main Results:
- Commonly encountered medication injuries in the GIT are detailed.
- Emerging drug agents and their potential mimics are discussed.
- Injury patterns, though organized by organ system, are often not site-specific.
Conclusions:
- Awareness of major morphologic patterns of drug injury is crucial for diagnosis.
- These patterns can be applied across multiple tissue sites in the GIT.
- Understanding these patterns facilitates the diagnostic process for medication-related GIT pathology.
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