Related Experiment Video
Updated: Apr 27, 2026

A Mouse 5/6th Nephrectomy Model That Induces Experimental Uremic Cardiomyopathy
Published on: November 7, 2017
Cardiovascular and non-cardiovascular mortality in dialysis patients: where is the link?
Kitty J Jager1, Bengt Lindholm2, David Goldsmith3
1ERA-EDTA Registry, Department of Medical Informatics, Academic Medical Center, University of Amsterdam , Amsterdam, The Netherlands.
Insights
Dialysis patients face high risks from both cardiovascular and non-cardiovascular causes of death. Future research should equally investigate non-cardiovascular mortality and potential links between infections and cardiovascular events in these patients.
Area of Science:
- Nephrology
- Cardiovascular Research
- Infectious Diseases
Background:
- Dialysis research has focused on cardiovascular mortality risk factors.
- Non-cardiovascular causes of death are equally prevalent in dialysis patients.
- Existing research suggests a link between cardiovascular disease and infections.
Approach:
- Review of current research trends in dialysis.
- Analysis of mortality data in dialysis populations.
- Identification of research gaps in non-cardiovascular causes of death.
Key Points:
- Non-cardiovascular mortality rivals cardiovascular mortality in dialysis patients.
- Infections are a potential contributing factor to mortality.
- Further investigation into the interplay between cardiovascular events and infections is needed.
Conclusions:
- Research efforts in dialysis must equally address non-cardiovascular mortality.
- Understanding the link between infections and cardiovascular events is crucial for improving patient outcomes.
- A comprehensive approach is needed to tackle the multifaceted mortality risks in dialysis.
Abstract:
Over the past decade, the research agenda in dialysis has been dominated by studies on risk factors associated with cardiovascular mortality. It has now become increasingly clear that in dialysis patients, non-cardiovascular causes of death are increased to the same extent as cardiovascular mortality, and therefore research efforts in this area deserve an equally prominent place on the nephrology research agenda. As previous research has suggested an association between cardiovascular disease and infections, more research on potential links between the causal pathways of cardiovascular events and infections is also warranted.
Related Concept Videos
Hemodialysis II: Procedure and Complications
Dialysis
Acute kidney injury develops suddenly and can be caused by pre-renal causes (e.g., hypovolemia, shock), intrinsic renal causes (e.g., acute tubular necrosis), or post-renal causes (e.g., urinary obstruction). In contrast, chronic renal failure progresses gradually over time and is often...
Dialysis
Hemodialysis III: Nursing Management
Hemodialysis I: Introduction
Peritoneal Dialysis II: Peritoneal Dialysis Systems and Complications

