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HDL-cholesterol is associated with systemic inflammation in cardiac syndrome X

E Tenekecioglu1, M Yilmaz, S Demir

  • 1Department of Cardiology, Bursa Yuksek Ihtisas Education and Research Hospital,Ankara Yolu, Yildirim/Bursa, Bursa, Turkey - erhantenekecioglu@yahoo.com.

Minerva Medica
|July 17, 2014
PubMed

Insights

Lower high-density lipoprotein cholesterol (HDL-C) is linked to increased inflammation in cardiac syndrome X (CSX). This suggests investigating HDL-C and inflammatory markers in CSX patients, aiming to raise HDL-C levels.

Area of Science:

  • Cardiology
  • Inflammation Research
  • Metabolic Syndrome

Background:

  • Microvascular inflammation is a known factor in cardiac syndrome X (CSX).
  • High-density lipoprotein cholesterol (HDL-C) possesses anti-inflammatory properties and supports endothelial function.
  • The relationship between HDL-C and inflammatory markers in CSX requires further elucidation.

Purpose of the Study:

  • To investigate the association between HDL-C levels and inflammatory markers in patients diagnosed with CSX.
  • To determine if lower HDL-C is a predictor of systemic inflammation in CSX.

Main Methods:

  • A study involving 100 patients with CSX and 80 healthy controls.
  • Evaluation of hematologic indices, lipid profiles, and C-reactive protein (CRP) levels.
  • Coronary angiography was performed on all participants.

Main Results:

  • CSX patients exhibited significantly higher CRP levels and lower HDL-C compared to controls.
  • Increased white blood cell (WBC) count and neutrophil-lymphocyte ratio (NLR) were observed in the CSX group.
  • Lower HDL-C levels were identified as a significant independent predictor of higher NLR in CSX patients.

Conclusions:

  • Reduced HDL-C is associated with systemic inflammation in individuals with CSX.
  • Investigating HDL-C and inflammatory markers is recommended for CSX patients presenting with typical angina and normal coronary arteries.
  • Therapeutic strategies aimed at increasing HDL-C levels should be considered for managing CSX.
Abstract

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