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Comparing echocardiographic assessment of systolic function with catheterization data in patients with single right

Nazia Husain, Janaki Gokhale, Lisa Nicholson

    Acta Cardiologica
    |July 18, 2014
    PubMed

    Insights

    Echocardiography did not correlate with catheterization in single right ventricle patients. Further research is needed to find the best non-invasive measure for systolic function in these complex cases.

    Area of Science:

    • Pediatric Cardiology
    • Echocardiography
    • Congenital Heart Disease

    Background:

    • Single right ventricle (SRV) physiology presents unique challenges for assessing systolic function.
    • Echocardiographic evaluation is crucial but lacks robust correlation with invasive hemodynamic data in SRV patients.
    • Limited data exist on the relationship between echocardiographic indices and catheterization-derived measurements in this population.

    Purpose of the Study:

    • To determine which echocardiographic measurement best correlates with catheterization-derived dP/dt (max) in patients with SRV.
    • To investigate the utility of various echocardiographic parameters in assessing systolic function in SRV.
    • To identify reliable non-invasive markers for systolic performance in single right ventricle physiology.

    Main Methods:

    • Simultaneous echocardiography and cardiac catheterization were performed in 27 SRV patients.
    • Echocardiographic parameters included fractional area change (FAC), displacement, TDI s'wave, myocardial performance index (MPI), global systolic strain, and global SR s wave.
    • Pearson correlation was used to examine the relationship between echocardiographic variables and catheterization-derived dP/dt (max).

    Main Results:

    • No significant correlations were found between catheterization-derived dP/dt (max) and any of the assessed echocardiographic systolic function measurements.
    • Echocardiographic parameters showed wide variability, with mean FAC of 27.15%, displacement of 7.35 mm, TDI s' of 4.98 cm/sec, MPI of 0.41, global strain of -14.85%, and global SR s wave of -1.03 sec(-1).
    • The study included patients with a median age of 11.4 months, highlighting the pediatric focus.

    Conclusions:

    • Catheterization-derived dP/dt (max) does not correlate with standard echocardiographic measurements of systolic function in SRV patients.
    • Current non-invasive echocardiographic parameters may not accurately reflect the in-vivo systolic performance in single right ventricle physiology.
    • Larger studies are necessary to identify and validate non-invasive parameters that effectively assess systolic function in SRV.
    Abstract

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